Yunqian Pan
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Explore the profile of Yunqian Pan including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1225
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Recent Articles
1.
Ding D, Blee A, Zhang J, Pan Y, Becker N, Maher 3rd L, et al.
Nat Commun
. 2023 Aug;
14(1):4671.
PMID: 37537199
Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens...
2.
Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, et al.
Mol Cell
. 2023 Jul;
83(15):2692-2708.e7.
PMID: 37478845
N-methyladenosine (mA) of mRNAs modulated by the METTL3-METTL14-WTAP-RBM15 methyltransferase complex and mA demethylases such as FTO play important roles in regulating mRNA stability, splicing, and translation. Here, we demonstrate that...
3.
Ma J, Zhou Y, Pan P, Yu H, Wang Z, Li L, et al.
Nat Commun
. 2023 Mar;
14(1):1810.
PMID: 37002234
53BP1 promotes nonhomologous end joining (NHEJ) over homologous recombination (HR) repair by mediating inactivation of DNA end resection. Ubiquitination plays an important role in regulating dissociation of 53BP1 from DNA...
4.
Huang Z, Li X, Tang B, Li H, Zhang J, Sun R, et al.
Cancer Res
. 2023 Jan;
83(6):875-889.
PMID: 36637424
Significance: The identification of a role for TRIM28 and SETDB1 in regulating CDK4/6-phosphorylated RB stability uncovers a combination strategy using CDK4/6 and SETDB1 inhibition to decrease RB degradation and inhibit...
5.
Yan Y, Shao J, Ding D, Pan Y, Tran P, Yan W, et al.
Chem Commun (Camb)
. 2022 Jan;
58(14):2383-2386.
PMID: 35080528
In this study, we identified 3-aminophthalic acid as a new ligand of cereblon (CRBN) E3 ubiquitin ligase and developed a phthalic acid-based O'PROTAC for degradation of the ERG transcription factor....
6.
Zhang J, Gao K, Xie H, Wang D, Zhang P, Wei T, et al.
Nat Commun
. 2021 Sep;
12(1):5716.
PMID: 34588438
Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and...
7.
Shao J, Yan Y, Ding D, Wang D, He Y, Pan Y, et al.
Adv Sci (Weinh)
. 2021 Aug;
8(20):e2102555.
PMID: 34397171
DNA-binding proteins, including transcription factors (TFs), play essential roles in various cellular processes and pathogenesis of diseases, deeming to be potential therapeutic targets. However, these proteins are generally considered undruggable...
8.
He Y, Wang L, Wei T, Xiao Y, Sheng H, Su H, et al.
J Clin Invest
. 2021 Jun;
131(14).
PMID: 34101624
Androgen receptor-positive prostate cancer (PCa) and estrogen receptor-positive luminal breast cancer (BCa) are generally less responsive to immunotherapy compared with certain tumor types such as melanoma. However, the underlying mechanisms...
9.
Shi L, Yan Y, He Y, Yan B, Pan Y, Orme J, et al.
Cancer Res
. 2021 Mar;
81(13):3593-3606.
PMID: 33762355
Molecular mechanisms underlying intratumoral androgenesis and aberrant androgen receptor (AR) activation in prostate cancer remain poorly understood. Here we demonstrate that ectopic expression of the E3 ubiquitin ligase adaptor speckle-type...
10.
Wu D, Yan Y, Wei T, Ye Z, Xiao Y, Pan Y, et al.
Cell Rep
. 2021 Feb;
34(7):108744.
PMID: 33596421
Acquisition of resistance to phosphatidylinositol 3-kinase (PI3K)/AKT-targeted monotherapy implies the existence of common resistance mechanisms independent of cancer type. Here, we demonstrate that PI3K/AKT inhibitors cause glycolytic crisis, acetyl-coenzyme A...