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Yun-Lin Liu

Explore the profile of Yun-Lin Liu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 35
Citations 184
Followers 0
Related Specialties
Chemistry
Biochemistry
Neurology
Top 10 Co-Authors
Jian Zhou
Guo-Shu Chen
Shu-Jie Chen
Feng Zhou
Zhi-Qing He
Jin-Sheng Yu
Long Chen
Xin Wang
Cheng Zhao
Hai Ren
Published In
Org Lett
Org Biomol Chem
Angew Chem Int Ed Engl
Chem Commun (Camb)
Chemistry
Affiliations
Soon will be listed here.
Recent Articles
1.
Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles
Xie D, Huang Y, Lin X, Kang Z, Ni C, Fu Y, et al.
Chemistry . 2024 Sep; 30(69):e202402654. PMID: 39243165
Herein a catalyst-free solvent-controlled method for the divergent synthesis of spirocyclopropyl and spiropyrazoline oxindoles from 3-ylideneoxindoles and ethyl diazoacetate was developed. With ClCHCHCl as the solvent, spirocyclopropyl oxindoles were obtained...
2.
Base-Mediated Allylic Defluorinative Functionalizations of β-CFH-1,3-enynes Enables the Construction of Terminal Monofluoroenynes
He Z, Chen S, Chen G, Dong B, Lin J, Zhong Y, et al.
Org Lett . 2024 Aug; 26(35):7468-7473. PMID: 39189837
The base-mediated allylic defluorinative functionalization of β-CFH-1,3-enynes with nucleophiles is described, affording terminal monofluoroalkenes bearing an alkynyl group in synthetically useful yields and / selectivities. Importantly, the resultant / mixture...
3.
Synthesis of Benzopyrone-Fused Hydrobenzo[,]indoles via Cascade Annulation of -Quinamines and 3-Formylchromones
Zhao C, Zhong A, Xie D, Ren H, Ni C, Chen G, et al.
Org Lett . 2024 Aug; 26(33):7031-7036. PMID: 39133549
A 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed cascade annulation reaction between -quinamines and 3-formylchromones was developed, affording a series of benzopyrone-fused hydrobenzo[,]indoles in moderate to high yields with excellent diastereoselectivity. This cascade reaction is...
4.
Base-Controlled Divergent Synthesis of Fluorine-Containing Benzo[4,5]imidazo[2,1-][1,3]thiazines from 2-Mercaptobenzimidazoles and β-CF-1,3-Enynes
He Z, Chen S, Chen G, Lin J, Wu J, Liu Y
J Org Chem . 2023 Aug; 88(18):13262-13271. PMID: 37619215
A base-controlled divergent cyclization between 2-mercaptobenzimidazoles and β-CF-1,3-enynes providing either trifluoromethylated or fluorinated benzo[4,5]imidazo[2,1-][1,3]thiazines has been developed. The β-CF-1,3-enyne, as a three-carbon synthon, underwent a 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU)-catalyzed tandem hydroamination/intramolecular...
5.
Catalyst-free formal [4+1]/[4+2] cyclization cascade sequence of isocyanides with two molecules of acylketene formed in situ from thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones
Luo J, Chen G, Chen S, Liu Y
Sci Bull (Beijing) . 2023 Jan; 65(8):670-677. PMID: 36659136
An expedient and economic approach for constructing O,O,N-spiro compounds consisting of both a 1,3-oxazine and a furan ring through a catalyst-free formal [4+1]/[4+2] cycloaddition cascade sequence of isocyanides with two...
6.
Synthesis of CF-Substituted Alkylamines, 1,2-Bisazoles, and 1,4,5,6-Tetrahydro-1,2,4-triazines from Newly Designed Tetrazole-Activated Trifluoromethyl Alkenes
Chen S, He Z, Chen G, Zhao C, Chen C, Zhuang Y, et al.
Org Lett . 2022 Dec; 24(50):9301-9305. PMID: 36516238
A new class of Michael acceptor, tetrazolyl-trifluoromethyl alkenes, has been discovered. They readily undergo Michael-type addition instead of addition-elimination reaction with aliphatic amines and azoles to furnish β-trifluoromethyl alkylamines and...
7.
-Trifluoropropylation of Azoles through -Vinylation and Sequential Hydrogenation
Chen S, Li J, He Z, Chen G, Zhuang Y, Chen C, et al.
J Org Chem . 2022 Nov; 87(22):15703-15712. PMID: 36331418
Installing a fluoroalkyl group onto the nitrogen atom of azoles represents a potential strategy for lead optimization in medicinal chemistry. Herein, we describe a method for the -trifluoropropylation of azoles....
8.
Catalytic divergent synthesis of imidazoles reaction condition-dependent [3 + 2] cyclization of TosMIC
Zhao C, Gu M, Chen Y, Hu X, Xu Y, Lin X, et al.
Org Biomol Chem . 2022 Oct; 20(44):8623-8627. PMID: 36314887
A base-catalyzed divergent synthesis of multisubstituted imidazoles through TosMIC-based [3 + 2] cyclization reaction has been developed. In the presence of ketenimines and BuONa, 1,4,5-trisubstituted imidazoles were obtained. Nonetheless, in...
9.
Ursolic acid inhibits Th17 cell differentiation via STAT3/RORγt pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression
Xu H, Yu A, Zhao D, Meng G, Wang L, Shan M, et al.
Innate Immun . 2022 May; 28(5):155-163. PMID: 35548957
Th17 cells represent important immune cells. Ursolic acid (UA) can regulate immune cell activities. This study was aimed to explore the effects of UA on Th17 cell differentiation and Schwann...
10.
Diversity-Oriented Synthesis of Fluoromethylated Arenes via Palladium-Catalyzed C-H Fluoromethylation of Aryl Iodides
Du Y, Chen S, Huang A, Chen Y, Liu Y, Song G, et al.
Org Lett . 2022 Feb; 24(6):1341-1345. PMID: 35129989
Herein we report the first versatile and expeditious method for the site-selective C-H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the...