Yun-Dong Wu
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Explore the profile of Yun-Dong Wu including associated specialties, affiliations and a list of published articles.
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191
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1530
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Recent Articles
1.
Wang H, Song L, Huang J, Wu F, Yang Z, Liu Y, et al.
Angew Chem Int Ed Engl
. 2025 Feb;
:e202500125.
PMID: 39972193
Vinyl ethers and allyl ethers are important motifs in natural products and pharmaceuticals. Among various methods toward their synthesis, direct allylic C-H functionalization of allyl ethers is one of the...
2.
Zeng Q, Chen J, Dai B, Jiang F, Wu Y
J Chem Theory Comput
. 2025 Jan;
21(2):991-1000.
PMID: 39801200
Accurate structural feature characterization of cyclic peptides (CPs), especially those with less than 10 residues and -peptide bonds, is challenging but important for the rational design of bioactive peptides. In...
3.
Jiang C, Ye Y, Kang W, Yang J, He Z, Cao Q, et al.
J Med Chem
. 2025 Jan;
68(2):1499-1510.
PMID: 39754579
CDK4/6 inhibitors are effective in treating HR/HER2 breast cancer but face limitations due to therapeutic resistance and hematological toxicity, particularly from strong CDK6 inhibition. To address these challenges, designing selective...
4.
Tan Y, Li S, Chen L, Huang J, Zhang C, Song L, et al.
Angew Chem Int Ed Engl
. 2024 Dec;
64(8):e202420370.
PMID: 39633550
Hydroboration of allenes is powerful and atom-economic approach to the synthesis of organoboranes, such as the highly versatile allylboranes. However, regarding regiocontrol, existing methods uniformly deliver the boron functionality to...
5.
Xu W, Sun T, Di Y, Hao X, Wu Y
Org Biomol Chem
. 2024 Sep;
22(40):8189-8197.
PMID: 39292510
Recently, several studies on the chemical synthesis of brevianamide A (BA) were reported. In particular, a highly efficient and remarkably selective synthetic strategy was reported by Lawrence's group. However, a...
6.
Deng Y, Sun T, Wu Y
J Org Chem
. 2024 Jul;
89(16):11173-11182.
PMID: 39072554
Although the concerted [3 + 2] mechanism of osmium-catalyzed asymmetric dihydroxylation has been generally accepted, the unusual nonlinear Hammett relationship induced by amine-type ligands remains unexplained. To understand this, we...
7.
Dai B, Chen J, Zeng Q, Geng H, Wu Y
J Phys Chem B
. 2024 Jul;
128(30):7322-7331.
PMID: 39028892
Cyclic peptides (CPs) are emerging as promising drug candidates. Numerous natural CPs and their analogs are effective therapeutics against various diseases. Notably, many of them contain peptidyl -prolyl bonds. Due...
8.
Zhao M, Xu W, Wu Y, Yang X, Wang J, Zhou J
J Am Chem Soc
. 2024 Jul;
146(29):20477-20493.
PMID: 38982945
Cobalt complexes with chiral quinox ligands effectively promote the enantioselective conjugate addition of enones using aryl, heteroaryl, and alkenyl halides and sulfonates. Additionally, a cobalt complex with a strongly donating...
9.
Dang Q, Deng Y, Sun T, Zhang Y, Li J, Zhang X, et al.
Nature
. 2024 Jun;
632(8024):313-319.
PMID: 38885695
Oligosaccharides have myriad functions throughout biological processes. Chemical synthesis of these structurally complex molecules facilitates investigation of their functions. With a dense concentration of stereocentres and hydroxyl groups, oligosaccharide assembly...
10.
Chen J, Dai B, Wu Y
J Chem Theory Comput
. 2024 May;
20(12):4977-4985.
PMID: 38758038
Molecular dynamics (MD) simulation is a popular method for elucidating the structures and functions of biomolecules. However, exploring the conformational space, especially for large systems with slow transitions, often requires...