Yuki Takechi-Haraya
Overview
Explore the profile of Yuki Takechi-Haraya including associated specialties, affiliations and a list of published articles.
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30
Citations
193
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Recent Articles
1.
Takechi-Haraya Y
Yakugaku Zasshi
. 2024 May;
144(5):511-519.
PMID: 38692926
Nanoparticles, including liposomes and lipid nanoparticles, have garnered global attention due to their potential applications in pharmaceuticals, vaccines, and gene therapies. These particles enable targeted delivery of new drug modalities...
2.
Takechi-Haraya Y, Ohgita T, Usui A, Nishitsuji K, Uchimura K, Abe Y, et al.
Sci Rep
. 2023 Nov;
13(1):19396.
PMID: 37938626
Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide...
3.
Takechi-Haraya Y, Usui A, Izutsu K, Abe Y
J Pharm Sci
. 2022 Dec;
112(3):648-652.
PMID: 36462707
The efficacy of mRNA-lipid nanoparticles (mRNA-LNPs) depends on several factors, including their size and morphology. This study presents a new technique to characterize mRNA-LNPs in an aqueous medium using atomic...
4.
Yamamoto E, Hosogi N, Takechi-Haraya Y, Izutsu K, Uchiyama N, Goda Y
Nanomedicine
. 2022 Nov;
47:102631.
PMID: 36410700
High-resolution cryogenic transmission electron microscopy (cryo-TEM) evidenced that doxorubicin sulfate crystals in liposomes (prepared by remote loading with ammonium sulfate) form folded, undulating, and fibrous crystals with a diameter of...
5.
Yang Z, Nill K, Takechi-Haraya Y, Playford M, Nguyen D, Yu Z, et al.
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955518
Both monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) play important roles in lipid metabolism, and diets enriched with either of these two fatty acids are associated with decreased...
6.
Nakao M, Takechi-Haraya Y, Ohgita T, Saito H, Demizu Y, Izutsu K, et al.
J Pharm Biomed Anal
. 2022 Jun;
218:114874.
PMID: 35696938
Owing to the relatively high molecular weight of macrocyclic peptides, investigation of the cellular uptake mechanism is required for the efficient design of macrocyclic peptides as potential drugs. We have...
7.
Takechi-Haraya Y, Ohgita T, Demizu Y, Saito H, Izutsu K, Sakai-Kato K
AAPS PharmSciTech
. 2022 May;
23(5):150.
PMID: 35596094
The present review discusses the current status and difficulties of the analytical methods used to evaluate size and surface modifications of nanoparticle-based pharmaceutical products (NPs) such as liposomal drugs and...
8.
Takechi-Haraya Y, Ohgita T, Kotani M, Kono H, Saito C, Tamagaki-Asahina H, et al.
Sci Rep
. 2022 Mar;
12(1):4959.
PMID: 35322082
We previously developed an amphipathic arginine-rich peptide, A2-17, which has high ability to directly penetrate across cell membranes. To understand the mechanism of the efficient cell-penetrating ability of the A2-17...
9.
Takechi-Haraya Y, Matsuoka M, Imai H, Izutsu K, Sakai-Kato K
Chem Phys Lipids
. 2020 Oct;
233:104992.
PMID: 33058816
Naturally sourced phospholipids are used in many liposomal pharmaceuticals. The present report describes a method to detect the effects of different egg yolk phosphatidylcholines (EPCs) on liposomal physicochemical properties. Five...
10.
Sakai-Kato K, Yoshida K, Takechi-Haraya Y, Izutsu K
Langmuir
. 2020 Oct;
36(42):12735-12744.
PMID: 33054220
Exosomes mediate communication between cells in the body by the incorporation and transfer of biological materials. To design an artificial liposome, which would mimic the lipid composition and physicochemical characteristics...