Yuk Kei Wan
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Explore the profile of Yuk Kei Wan including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
363
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Recent Articles
11.
Pratanwanich P, Yao F, Chen Y, Koh C, Kei Wan Y, Hendra C, et al.
Nat Biotechnol
. 2021 Jul;
39(11):1394-1402.
PMID: 34282325
RNA modifications, such as N-methyladenosine (mA), modulate functions of cellular RNA species. However, quantifying differences in RNA modifications has been challenging. Here we develop a computational method, xPore, to identify...
12.
Zhou P, Kei Wan Y, Chan B, Choi G, Wong A
STAR Protoc
. 2021 Jan;
2(1):100255.
PMID: 33490975
The CRISPR-Cas system coupled with Combinatorial Genetics (CombiGEM) enables systematic analysis of high-order genetic perturbations that are important for understanding biological processes and discovering therapeutic target combinations. Here, we present...
13.
Kei Wan Y, Choi G, Wong A
Methods Mol Biol
. 2020 Oct;
2199:3-12.
PMID: 33125641
Exploring how combinatorial mutations can be combined to optimize protein functions is important to guide protein engineering. Given the vast combinatorial space of changing multiple amino acids, identifying the top-performing...
14.
Zhou P, Chan B, Kei Wan Y, Yuen C, Choi G, Li X, et al.
Cell Rep
. 2020 Aug;
32(6):108020.
PMID: 32783942
We present a CRISPR-based multi-gene knockout screening system and toolkits for extensible assembly of barcoded high-order combinatorial guide RNA libraries en masse. We apply this system for systematically identifying not...