Yujun George Zheng
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Explore the profile of Yujun George Zheng including associated specialties, affiliations and a list of published articles.
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32
Citations
656
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Recent Articles
1.
Delaney K, Tan M, Zhu Z, Gao J, Dai L, Kim S, et al.
Cell Discov
. 2021 Dec;
7(1):122.
PMID: 34961760
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of a new type of histone posttranslational modification, lysine methacrylation (Kmea), corresponding...
2.
Chen S, Wiewiora R, Meng F, Babault N, Ma A, Yu W, et al.
Elife
. 2019 May;
8.
PMID: 31081496
Elucidating the conformational heterogeneity of proteins is essential for understanding protein function and developing exogenous ligands. With the rapid development of experimental and computational methods, it is of great interest...
3.
Zhang J, Qian K, Yan C, He M, Jassim B, Ivanov I, et al.
Medchemcomm
. 2017 Jun;
8(2):440-444.
PMID: 28649316
Protein arginine methyltransferase 1 (PRMT1) is a key player for the dynamic regulation of arginine methylation. Its dysregulation and aberrant expression are implicated in various pathological conditions, and a plethora...
4.
Madia V, Benedetti R, Letizia Barreca M, Ngo L, Pescatori L, Messore A, et al.
ChemMedChem
. 2017 Mar;
12(16):1359-1368.
PMID: 28346821
Human p300 is a polyhedric transcriptional coactivator that plays a crucial role in acetylating histones on specific lysine residues. A great deal of evidence shows that p300 is involved in...
5.
Valerio D, Xu H, Chen C, Hoshii T, Eisold M, Delaney C, et al.
Cancer Res
. 2017 Feb;
77(7):1753-1762.
PMID: 28202522
Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that are of great current interest. In this study, we conducted an RNAi-based screen to identify druggable chromatin regulator-based targets...
6.
Li R, Xu J, Fu C, Zhang J, Zheng Y, Jia H, et al.
Elife
. 2016 Oct;
5.
PMID: 27787197
Blockade of lysosomal calcium release due to lysosomal lipid accumulation has been shown to inhibit mTORC1 signaling. However, the mechanism by which lysosomal calcium regulates mTORC1 has remained undefined. Herein...
7.
Blazer L, Li F, Kennedy S, Zheng Y, Arrowsmith C, Vedadi M
SLAS Discov
. 2016 Sep;
22(1):32-39.
PMID: 27581605
BCDIN3D is an RNA-methyltransferase that O-methylates the 5' phosphate of RNA and regulates microRNA maturation. To discover small-molecule inhibitors of BCDIN3D, a suite of biochemical assays was developed. A radiometric...
8.
Eberhardt A, Hansen J, Koster J, Lotta Jr L, Wang S, Livingstone E, et al.
Oncotarget
. 2016 Aug;
7(39):63629-63639.
PMID: 27571165
Amplification or overexpression of MYCN is associated with poor prognosis of human neuroblastoma. We have recently defined a MYCN-dependent transcriptional signature, including protein arginine methyltransferase 1 (PRMT1), which identifies a...
9.
Zhou R, Xie Y, Hu H, Hu G, Patel V, Zhang J, et al.
J Chem Inf Model
. 2015 Nov;
55(12):2623-32.
PMID: 26562720
Protein arginine methyltransferases (PRMTs) catalyze the posttranslational methylation of arginine, which is important in a range of biological processes, including epigenetic regulation, signal transduction, and cancer progression. Although previous studies...
10.
Luan Y, Blazer L, Hu H, Hajian T, Zhang J, Wu H, et al.
Org Biomol Chem
. 2015 Nov;
14(2):631-638.
PMID: 26541578
The histone methyltransferase MLL1 has been linked to translocation-associated gene fusion in childhood leukemias and is an attractive drug target. High-throughput biochemical analysis of MLL1 methyltransferase activity requires the production...