Yujia A Chan
Overview
Explore the profile of Yujia A Chan including associated specialties, affiliations and a list of published articles.
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13
Citations
626
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Recent Articles
1.
Eid F, Chen A, Chan K, Huang Q, Zheng Q, Tobey I, et al.
Nat Commun
. 2024 Aug;
15(1):6602.
PMID: 39097583
Broadening gene therapy applications requires manufacturable vectors that efficiently transduce target cells in humans and preclinical models. Conventional selections of adeno-associated virus (AAV) capsid libraries are inefficient at searching the...
2.
Huang Q, Chan K, Wu J, Botticello-Romero N, Zheng Q, Lou S, et al.
Science
. 2024 May;
384(6701):1220-1227.
PMID: 38753766
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an adeno-associated virus (AAV) capsid, BI-hTFR1, that...
3.
Huang Q, Chan K, Lou S, Keyes C, Wu J, Botticello-Romero N, et al.
bioRxiv
. 2024 Jan;
PMID: 38187643
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an AAV capsid, BI-hTFR1, that binds human...
4.
Huang Q, Chen A, Chan K, Sorensen H, Barry A, Azari B, et al.
PLoS Biol
. 2023 Jul;
21(7):e3002112.
PMID: 37467291
Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of cell macromolecules. We engineered peptide-modified adeno-associated virus (AAV) capsids that transduce the brain...
5.
Krolak T, Chan K, Kaplan L, Huang Q, Wu J, Zheng Q, et al.
Nat Cardiovasc Res
. 2022 May;
1(4):389-400.
PMID: 35571675
Endothelial cells have a crucial role in nervous system function, and mounting evidence points to endothelial impairment as a major contributor to a wide range of neurological diseases. However, tools...
6.
Chang R, Stanley J, Robinson M, Sher J, Li Z, Chan Y, et al.
EMBO J
. 2020 Oct;
39(23):e104523.
PMID: 33073387
Oxidative stress alters cell viability, from microorganism irradiation sensitivity to human aging and neurodegeneration. Deleterious effects of protein carbonylation by reactive oxygen species (ROS) make understanding molecular properties determining ROS ...
7.
Chang E, Tsai S, Aristizabal M, Wells J, Coulombe Y, Busatto F, et al.
Nat Commun
. 2019 Sep;
10(1):4265.
PMID: 31537797
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops....
8.
Lau Y, Stirling F, Kuo J, Karrenbelt M, Chan Y, Riesselman A, et al.
Nucleic Acids Res
. 2017 May;
45(11):6971-6980.
PMID: 28499033
The ability to rewrite large stretches of genomic DNA enables the creation of new organisms with customized functions. However, few methods currently exist for accumulating such widespread genomic changes in...
9.
Brown D, Chan Y, Desai P, Grzesik P, Oldfield L, Vashee S, et al.
Nucleic Acids Res
. 2016 Dec;
45(7):e50.
PMID: 27980064
The delivery of large DNA vectors (>100 000 bp) remains a limiting step in the engineering of mammalian cells and the development of human artificial chromosomes (HACs). Yeast is commonly...
10.
Chan Y, Hieter P, Stirling P
Trends Genet
. 2014 May;
30(6):245-53.
PMID: 24794811
The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have...