Yuichi Yagita
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Explore the profile of Yuichi Yagita including associated specialties, affiliations and a list of published articles.
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10
Citations
259
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Recent Articles
1.
Carrillo Roas S, Yagita Y, Murphy P, Kurzbauer R, Clausen T, Zavodszky E, et al.
Mol Cell
. 2025 Jan;
85(4):815-828.e10.
PMID: 39879985
Unassembled and partially assembled subunits of multi-protein complexes have emerged as major quality control clients, particularly under conditions of imbalanced gene expression such as stress, aging, and aneuploidy. The factors...
2.
Yagita Y, Zavodszky E, Peak-Chew S, Hegde R
Cell
. 2023 Jul;
186(16):3443-3459.e24.
PMID: 37480851
Cells contain numerous abundant molecular machines assembled from multiple subunits. Imbalances in subunit production and failed assembly generate orphan subunits that are eliminated by poorly defined pathways. Here, we determined...
3.
Yagita Y, Abe Y, Fujiki Y
J Cell Sci
. 2022 Apr;
135(9).
PMID: 35437598
Mammalian PEX16 has been considered essential for generating and maintaining peroxisomal membranes. This view is based primarily on the finding that fibroblasts from several PEX16-deficient patients are devoid of peroxisomal...
4.
Yamashita K, Tamura S, Honsho M, Yada H, Yagita Y, Kosako H, et al.
J Cell Biol
. 2020 Aug;
219(10).
PMID: 32854114
Peroxisomal matrix proteins are imported into peroxisomes via membrane-bound docking/translocation machinery. One central component of this machinery is Pex14p, a peroxisomal membrane protein involved in the docking of Pex5p, the...
5.
ODonnell J, Phillips B, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, et al.
Elife
. 2020 May;
9.
PMID: 32459176
Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in...
6.
Yagita Y, Shinohara K, Abe Y, Nakagawa K, Al-Owain M, Alkuraya F, et al.
J Biol Chem
. 2016 Dec;
292(2):691-705.
PMID: 27899449
Acyl-CoA binding domain-containing 5 (ACBD5) is a peroxisomal protein that carries an acyl-CoA binding domain (ACBD) at its N-terminal region. The recent identification of a mutation in the ACBD5 gene...
7.
Liu Y, Yagita Y, Fujiki Y
Traffic
. 2016 Jan;
17(4):433-55.
PMID: 26777132
Correct targeting of peroxisomal membrane proteins (PMPs) is essential for the formation and maintenance of functional peroxisomes. Activities of Pex19p to interact with PMPs on one hand and Pex3p on...
8.
Yagita Y, Hiromasa T, Fujiki Y
J Cell Biol
. 2013 Mar;
200(5):651-66.
PMID: 23460677
Tail-anchored (TA) proteins are anchored into cellular membranes by a single transmembrane domain (TMD) close to the C terminus. Although the targeting of TA proteins to peroxisomes is dependent on...
9.
Yagita Y, Kuse N, Kuroki K, Gatanaga H, Carlson J, Chikata T, et al.
J Virol
. 2012 Dec;
87(4):2253-63.
PMID: 23236061
Pol283-8-specific, HLA-B*51:01-restricted, cytotoxic T cells (CTLs) play a critical role in the long-term control of HIV-1 infection. However, these CTLs select for the reverse transcriptase (RT) I135X escape mutation, which...
10.
Fujiki Y, Yagita Y, Matsuzaki T
Biochim Biophys Acta
. 2012 Jun;
1822(9):1337-42.
PMID: 22705440
Peroxisome is a single-membrane organelle in eukaryotes. The functional importance of peroxisomes in humans is highlighted by peroxisome-deficient peroxisome biogenesis disorders (PBDs) such as Zellweger syndrome (ZS). Gene defects of...