Yuichi J Machida
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Explore the profile of Yuichi J Machida including associated specialties, affiliations and a list of published articles.
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25
Citations
1209
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Recent Articles
1.
Welter A, Palani S, Machida Y, Schellenberg M, Machida Y
J Biol Chem
. 2025 Jan;
301(2):108175.
PMID: 39798873
The host-range mutant of rabbitpox virus (RPXV) with a deletion in the gene encoding the serpin serine protease inhibitor 1 (SPI-1) fails to replicate efficiently in restrictive host cells. Depletion...
2.
Erber L, Groehler 4th A, Cyuzuzo C, Baker-Wainwright J, Maskey R, Li L, et al.
Sci Rep
. 2024 Dec;
14(1):30919.
PMID: 39730693
Exposure to reactive oxygen species (ROS) can induce DNA-protein crosslinks (DPCs), unusually bulky DNA lesions that block replication and transcription and play a role in aging, cancer, cardiovascular disease, and...
3.
Palani S, Machida Y, Alvey J, Mishra V, Welter A, Cui G, et al.
Nat Commun
. 2024 Mar;
15(1):2064.
PMID: 38453899
FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic disorders with developmental defects. Despite...
4.
Welter A, Machida Y
Front Mol Biosci
. 2023 Jan;
9:1081166.
PMID: 36589246
Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease involved in two seemingly distinct processes: DNA...
5.
Kelly R, Huehls A, Venkatachalam A, Huntoon C, Machida Y, Karnitz L
J Biol Chem
. 2022 Mar;
298(4):101777.
PMID: 35231445
Replication stress impedes DNA polymerase progression causing activation of the ataxia telangiectasia and Rad3-related signaling pathway, which promotes the intra-S phase checkpoint activity through phosphorylation of checkpoint kinase 1 (Chk1)....
6.
7.
Popay T, Wang J, Adams C, Howard G, Codreanu S, Sherrod S, et al.
Elife
. 2021 Jan;
10.
PMID: 33416496
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may...
8.
Kojima Y, Machida Y
Environ Mol Mutagen
. 2020 Apr;
61(7):716-729.
PMID: 32329115
Many environmental carcinogens cause DNA damage, which can result in mutations and other alterations in genomic DNA if not repaired promptly. Because of the bulkiness of the lesions, DNA-protein crosslinks...
9.
Kojima Y, Machida Y, Palani S, Caulfield T, Radisky E, Kaufmann S, et al.
Nat Commun
. 2020 Mar;
11(1):1318.
PMID: 32165630
Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease...
10.
Kurmi K, Hitosugi S, Yu J, Boakye-Agyeman F, Wiese E, Larson T, et al.
Cell Metab
. 2018 Sep;
28(6):833-847.e8.
PMID: 30174304
How mitochondrial metabolism is altered by oncogenic tyrosine kinases to promote tumor growth is incompletely understood. Here, we show that oncogenic HER2 tyrosine kinase signaling induces phosphorylation of mitochondrial creatine...