Yugandhar Kothapalli
Overview
Explore the profile of Yugandhar Kothapalli including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
2
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0
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Recent Articles
1.
Kothapalli Y, Chu C, Singh U
J Org Chem
. 2024 Jun;
89(13):9313-9321.
PMID: 38900839
β-l-5-(()-2-Bromovinyl)-1-((2,4)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) uracil (l-BHDU, ) is a potent and selective inhibitor of the varicella-zoster virus (VZV). l-BHDU () has demonstrated excellent -VZV activity and is a preclinical candidate to treat chickenpox,...
2.
Kothapalli Y, Jones R, Chu C, Singh U
Molecules
. 2024 May;
29(10).
PMID: 38792251
The FDA has approved several drugs based on the fluorinated nucleoside pharmacophore, and numerous drugs are currently in clinical trials. Fluorine-containing nucleos(t)ides offer significant antiviral and anticancer activity. The insertion...
3.
Singh U, Konreddy A, Kothapalli Y, Liu D, Lloyd M, Annavarapu V, et al.
J Med Chem
. 2023 May;
66(10):7038-7053.
PMID: 37140467
Varicella zoster virus (VZV) establishes lifelong infection after primary disease and can reactivate. Several drugs are approved to treat VZV diseases, but new antivirals with greater potency are needed. Previously,...