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Yuan-Shek Chen

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Articles 6
Citations 42
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Recent Articles
1.
Xiao D, Ling K, Tarnowski T, Humeniuk R, German P, Mathias A, et al.
Anal Biochem . 2021 Jan; 617:114118. PMID: 33508271
Remdesivir (RDV) is a phosphoramidate prodrug designed to have activity against a broad spectrum of viruses. Following IV administration, RDV is rapidly distributed into cells and tissues and simultaneously metabolized...
2.
Xiao D, Ling K, Tarnowski T, Majeed S, German P, Kearney B, et al.
Anal Biochem . 2020 Feb; 593:113611. PMID: 32035040
Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are both tenofovir (TFV) prodrugs, with the same active intracellular metabolite, TFV-diphosphate (TFV-DP). TAF delivers TFV-DP to target cells more efficiently and...
3.
Kim H, Kosinski P, Kung C, Dang L, Chen Y, Yang H, et al.
J Chromatogr B Analyt Technol Biomed Life Sci . 2017 Jul; 1061-1062:89-96. PMID: 28711785
Many hemolytic anemias results in major metabolic abnormalities: two common metabolite abnormalities include increased levels of 2,3-diphosphoglycerate (2,3-DPG) and decreased levels of adenosine triphosphate (ATP). To better monitor the concentration...
4.
Xue Y, Melo B, Vallejo M, Zhao Y, Tang L, Chen Y, et al.
Biomed Chromatogr . 2012 Jan; 26(10):1215-27. PMID: 22213422
We proposed an integrated bioanalytical method development and validation approach: (1) method screening based on analyte's physicochemical properties and metabolism information to determine the most appropriate extraction/analysis conditions; (2) preliminary...
5.
Zhao Y, Cao J, Chen Y, Zhu Y, Patrick C, Chien B, et al.
Bioanalysis . 2010 Nov; 1(5):895-903. PMID: 21083061
Background: Tetrahydrobiopterin (BH4) is a naturally occurring pteridine and cofactor for a variety of enzymes, including phenylalanine-4-hydroxylase, nitric oxide synthetase and glyceryl ether monooxygenase. BH4 is readily oxidized to dihydrobiopterin...
6.
Xu P, Chen Y, Lin S, Lu T
J Org Chem . 2002 Apr; 67(7):2309-14. PMID: 11925246
The development of a highly efficient and stereoselective methodology for the preparation of alpha-amino acids is described. The chiral template, tricyclic iminolactone 7, was synthesized from (1R)-(+)-camphor in five steps...