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Yu-Yen Ou

Explore the profile of Yu-Yen Ou including associated specialties, affiliations and a list of published articles. Areas
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Articles 54
Citations 560
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Recent Articles
1.
Chuang C, Liu Y, Jhang W, Wei S, Ou Y
J Chem Inf Model . 2025 Feb; 65(5):2685-2694. PMID: 39967508
Interleukin-6 (IL-6) is a critical cytokine involved in immune regulation, inflammation, and the pathogenesis of various diseases, including autoimmune disorders, cancer, and the cytokine storm associated with severe COVID-19. Identifying...
2.
Chang Y, Liu Y, Jhang W, Wei S, Ou Y
J Chem Inf Model . 2025 Feb; 65(4):2145-2157. PMID: 39916334
Calcium ions (Ca) are crucial for various physiological processes, including neurotransmission and cardiac function. Dysregulation of Ca homeostasis can lead to serious health conditions such as cardiac arrhythmias and hypertension....
3.
Shah S, Rafi M, Malik M, Malik S, Ou Y
Int J Biol Macromol . 2025 Jan; 294:139522. PMID: 39761890
Glucose transporters are essential carrier proteins that function on the phospholipid bilayer to facilitate glucose diffusion across cell membranes. The transporters play many physiological and pathological roles in addition to...
4.
Le V, Malik M, Lin Y, Liu Y, Chang Y, Ou Y
Comput Biol Med . 2024 Dec; 185():109541. PMID: 39653625
Adenosine triphosphate plays a vital role in providing energy and enabling key cellular processes through interactions with binding proteins. The increasing amount of protein sequence data necessitates computational methods for...
5.
Malik M, Le V, Shah S, Ou Y
J Biomol Struct Dyn . 2024 Nov; :1-10. PMID: 39576667
Secondary active transporters play a crucial role in cellular physiology by facilitating the movement of molecules across cell membranes. Identifying the functional classes of these transporters, particularly amino acid and...
6.
Chuang C, Liu Y, Ou Y
Int J Biol Macromol . 2024 Oct; 281(Pt 1):136252. PMID: 39366619
Neoantigens, derived from tumor-specific mutations, play a crucial role in eliciting anti-tumor immune responses and have emerged as promising targets for personalized cancer immunotherapy. Accurately identifying neoantigens from a vast...
7.
Le V, Tseng Y, Liu Y, Malik M, Ou Y
Int J Biol Macromol . 2024 Sep; 280(Pt 3):136048. PMID: 39332561
Vesicular transport is a critical cellular process responsible for the proper organization and functioning of eukaryotic cells. This mechanism relies on specialized vesicles that shuttle macromolecules, such as proteins, across...
8.
Liu Y, Lin Y, Chang Y, Chuang C, Ou Y
J Mol Biol . 2024 Aug; 436(22):168769. PMID: 39214282
Deciphering the mechanisms governing protein-DNA interactions is crucial for understanding key cellular processes and disease pathways. In this work, we present a powerful deep learning approach that significantly advances the...
9.
Malik M, Chang Y, Liu Y, Le V, Ou Y
J Chem Inf Model . 2024 Aug; 64(24):9125-9134. PMID: 39133248
Mitochondrial carriers (MCs) are essential proteins that transport metabolites across mitochondrial membranes and play a critical role in cellular metabolism. ADP/ATP (adenosine diphosphate/adenosine triphosphate) is one of the most important...
10.
Le V, Zhan Z, Vu T, Malik M, Ou Y
J Mol Graph Model . 2024 Apr; 130:108777. PMID: 38642500
This study delves into the prediction of protein-peptide interactions using advanced machine learning techniques, comparing models such as sequence-based, standard CNNs, and traditional classifiers. Leveraging pre-trained language models and multi-view...