Youtong Huang
Overview
Explore the profile of Youtong Huang including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
212
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Recent Articles
1.
Scott-Hewitt N, Mahoney M, Huang Y, Korte N, de Soysa T, Wilton D, et al.
Cell
. 2024 Jun;
187(16):4193-4212.e24.
PMID: 38942014
Neuroimmune interactions mediate intercellular communication and underlie critical brain functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical interactions and the secretion of molecules. One such secreted factor, the...
2.
Scott-Hewitt N, Huang Y, Stevens B
Ann N Y Acad Sci
. 2023 Jun;
1525(1):5-27.
PMID: 37272510
Changes in synaptic function are an early hallmark of neuropathological conditions that often precede symptom onset, with mounting genetic, transcriptional, and epidemiological evidence implicating microglia in this process. The correlation...
3.
Huang Y, Lemke G
STAR Protoc
. 2022 Dec;
3(4):101891.
PMID: 36472212
Here, we describe a highly adaptable toolbox for characterizing and analyzing molecular and histopathological changes in Alzheimer's disease (AD) mouse models. We detail optimized and streamlined approaches from sample preparation...
4.
Huang Y, Lemke G
Proc Natl Acad Sci U S A
. 2022 Oct;
119(41):e2204306119.
PMID: 36191221
Recurrent seizure is a common comorbidity in early-stage Alzheimer's disease (AD) and may contribute to AD pathogenesis and cognitive decline. Similarly, many mouse models of Alzheimer's disease that overproduce amyloid...
5.
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages
Jimenez-Garcia L, Mayer C, Burrola P, Huang Y, Shokhirev M, Lemke G
Front Immunol
. 2022 Aug;
13:960401.
PMID: 35967387
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely...
6.
Lemke G, Huang Y
J Exp Med
. 2022 Jun;
219(8).
PMID: 35731195
Dense-core plaques, whose centers contain highly polymerized and compacted aggregates of amyloid β peptides, are one of the two defining histopathological features of Alzheimer's disease. Recent findings indicate that these...
7.
Huang Y, Happonen K, Burrola P, OConnor C, Hah N, Huang L, et al.
Nat Immunol
. 2021 Apr;
22(5):586-594.
PMID: 33859405
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer's...