Young Jun Im
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Explore the profile of Young Jun Im including associated specialties, affiliations and a list of published articles.
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60
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1246
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Recent Articles
11.
Ryu M, Sung C, Im Y, Chun C
Molecules
. 2020 Mar;
25(5).
PMID: 32121012
JNK and p38 are important mitogen-activated protein kinases (MAPKs) that respond to stress stimuli. The stress-activated MAPKs associated with apoptotic cell death play vital roles in mammalian cells. , which...
12.
Tan L, Tong J, Chun C, Im Y
Biochem Biophys Res Commun
. 2019 Oct;
520(2):466-472.
PMID: 31607485
The steroidogenic acute regulatory protein (StAR)-related lipid transfer domain-4 (STARD4) is a sterol-binding protein that is involved in cholesterol homeostasis by intracellular sterol transport. In this work, we determined the...
13.
Guo R, Im Y, Shin S, Jeong K, Rhee J, Kim Y
Emerg Microbes Infect
. 2019 Jun;
8(1):934-945.
PMID: 31237474
Cytoskeletal rearrangement and acute cytotoxicity occur in infected host cells. RtxA1 toxin, a multifunctional autoprocessing repeats-in-toxin (MARTX), is essential for the pathogenesis of and the programmed necrotic cell death. In...
14.
Tong J, Tan L, Chun C, Im Y
PLoS One
. 2019 Feb;
14(2):e0211724.
PMID: 30721249
Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of lipid transfer proteins conserved in eukaryotes. ORP1 transports cholesterol at the interface between the late endosomes/lysosomes (LELs) and the...
15.
Tong J, Manik M, Im Y
Proc Natl Acad Sci U S A
. 2018 Jan;
115(5):E856-E865.
PMID: 29339490
Membrane contact sites (MCSs) in eukaryotic cells are hotspots for lipid exchange, which is essential for many biological functions, including regulation of membrane properties and protein trafficking. Lipid transfer proteins...
16.
Lee M, Tan L, Yang H, Im Y, Im Y
Sci Rep
. 2017 Dec;
7(1):16837.
PMID: 29203903
Peroxisome proliferator-activator receptor (PPAR) γ is a nuclear hormone receptor that regulates glucose homeostasis, lipid metabolism, and adipocyte function. PPARγ is a target for thiazolidinedione (TZD) class of drugs which...
17.
Manik M, Yang H, Tong J, Im Y
Structure
. 2017 Mar;
25(4):617-629.e3.
PMID: 28319008
Yeast Osh1 belongs to the oxysterol-binding protein (OSBP) family of proteins and contains multiple targeting modules optimized for lipid transport at the nucleus-vacuole junction (NVJ). The key determinants for NVJ...
18.
Cai B, Liao A, Lee K, Ban J, Yang H, Im Y, et al.
Steroids
. 2016 Nov;
116:45-51.
PMID: 27770617
A series of methotrexate-diosgenin conjugates was designed and synthesized to enhance the passive internalization of methotrexate (MTX) into transport-resistant cells. The inhibitory effects of these conjugates on dihydrofolate reductase (DHFR),...
19.
Choi M, Won E, Shin J, Kim S, Lee W, Kim M, et al.
Antimicrob Agents Chemother
. 2016 Apr;
60(6):3653-61.
PMID: 27044550
We investigated the azole resistance mechanisms and clinical features of fluconazole-nonsusceptible (FNS) isolates of Candida tropicalis recovered from Korean surveillance cultures in comparison with fluconazole-less-susceptible (FLS) isolates. Thirty-five clinical isolates...
20.
Youn H, Kim T, Kim M, Kang G, Kang J, Lee J, et al.
Sci Rep
. 2016 Jan;
6:19681.
PMID: 26805589
Quinolinate phosphoribosyltransferase (QPRT) catalyses the production of nicotinic acid mononucleotide, a precursor of de novo biosynthesis of the ubiquitous coenzyme nicotinamide adenine dinucleotide. QPRT is also essential for maintaining the...