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Young Ah Seo

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Articles 29
Citations 651
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Recent Articles
1.
Choi E, Aring L, Peng Y, Correia A, Lieberman A, Iwase S, et al.
JCI Insight . 2024 Oct; 9(20). PMID: 39435657
Solute carrier family 39, member 8 (SLC39A8), is a transmembrane transporter that mediates the cellular uptake of zinc, iron, and manganese (Mn). Human genetic studies document the involvement of SLC39A8...
2.
Choi E, Rajendiran T, Soni T, Park J, Aring L, Muraleedharan C, et al.
Nat Commun . 2024 Jun; 15(1):4775. PMID: 38839750
The metal ion transporter SLC39A8 is associated with physiological traits and diseases, including blood manganese (Mn) levels and inflammatory bowel diseases (IBD). The mechanisms by which SLC39A8 controls Mn homeostasis...
3.
Yang C, Leung C, Lee J, Park S, Jansen E, Seo Y
J Nutr . 2023 Nov; 154(1):213-223. PMID: 37984743
Background: Manganese (Mn) is an essential micronutrient, but inadequate or excess Mn intake can have a detrimental impact on human health. Despite the essentiality, little is known about the relationship...
4.
Kim S, Seo Y
Methods Enzymol . 2023 Sep; 687:185-206. PMID: 37666632
Manganese (Mn) is an essential micronutrient required for fundamental cell functions and vital physiological processes. More than a dozen putative Mn transporters have been described over the last two decades,...
5.
Ekaputri S, Choi E, Sabelli M, Aring L, Green K, Chang J, et al.
Proc Natl Acad Sci U S A . 2022 Jun; 119(26):e2121400119. PMID: 35737834
Deficiencies of the transmembrane iron-transporting protein ferroportin (FPN1) cause the iron misdistribution that underlies ferroportin disease, anemia of inflammation, and several other human diseases and conditions. A small molecule natural...
6.
Aring L, Choi E, Kopera H, Lanigan T, Iwase S, Klionsky D, et al.
J Neurochem . 2021 Nov; 160(3):356-375. PMID: 34837396
Neurodegeneration with brain iron accumulation (NBIA) is a clinically and genetically heterogeneous group of neurodegenerative diseases characterized by the abnormal accumulation of brain iron and the progressive degeneration of the...
7.
Wang X, Seo Y, Park S
Environ Res . 2021 Apr; 197:111190. PMID: 33872646
Background: Selenium is an essential trace element that shows beneficial or adverse health effects depending on the dose. Laboratory studies suggest that high selenium may contribute to the development of...
8.
Seo Y, Choi E, Aring L, Paschall M, Iwase S
Front Genet . 2021 Jan; 11:558725. PMID: 33408735
Manganese (Mn), primarily acquired through diet, is required for brain function and development. Epidemiological studies have found an association between both low and high levels of Mn and impaired neurodevelopment...
9.
Kho M, Smith J, Verweij N, Shang L, Ryan K, Zhao W, et al.
J Nutr . 2020 Aug; 150(10):2635-2645. PMID: 32840624
Background: Excess sodium intake and insufficient potassium intake are risk factors for hypertension, but there is limited knowledge regarding genetic factors that influence intake. Twenty-hour or half-day urine samples provide...
10.
Bakulski K, Seo Y, Hickman R, Brandt D, Vadari H, Hu H, et al.
J Alzheimers Dis . 2020 Jul; 76(4):1215-1242. PMID: 32651318
Alzheimer's disease and related dementias lack effective treatment or cures and are major public health challenges. Risk for Alzheimer's disease and related dementias is partially attributable to environmental factors. The...