You-Qing Zhang
Overview
Explore the profile of You-Qing Zhang including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
17
Citations
431
Followers
0
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Recent Articles
1.
Liu Y, Jin Q, Ding Q, Hao X, Mo T, Yan S, et al.
ChemMedChem
. 2020 Jul;
15(16):1562-1570.
PMID: 32613743
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches...
2.
Liu Y, Jin Q, Zou Y, Ding Q, Yan S, Wang Z, et al.
J Med Chem
. 2020 Feb;
63(6):2958-2973.
PMID: 32077280
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach...
3.
Shen W, Taylor B, Jin Q, Nguyen-Tran V, Meeusen S, Zhang Y, et al.
Nat Commun
. 2015 Oct;
6:8372.
PMID: 26496802
Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made in regulating insulin secretion from β-cells in diabetic patients, no pharmacological agents have been...
4.
Shen W, Tremblay M, Deshmukh V, Wang W, Filippi C, Harb G, et al.
J Am Chem Soc
. 2013 Jan;
135(5):1669-72.
PMID: 23330637
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based...
5.
Kritzik M, Lago C, Kayali A, Arnaud-Dabernat S, Liu G, Zhang Y, et al.
Endocrine
. 2010 Oct;
37(2):312-21.
PMID: 20960269
The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the...
6.
Zhang Y, Resta S, Jung B, Barrett K, Sarvetnick N
Am J Physiol Gastrointest Liver Physiol
. 2009 Aug;
297(4):G768-80.
PMID: 19643954
Several lines of studies have suggested that activins are critical mediators of inflammation and tissue repair. As activins and their receptors are expressed in the gastrointestinal tract, we tested the...
7.
Zhang Y, Sterling L, Stotland A, Hua H, Kritzik M, Sarvetnick N
Dev Dyn
. 2008 Apr;
237(5):1255-67.
PMID: 18393305
Nodal and its antagonist, Lefty, are important mediators specifying the laterality of the organs during embryogenesis. Nodal signals through activin receptors in the presence of its co-receptor, Cripto. In the...
8.
Arnaud-Dabernat S, Kritzik M, Kayali A, Zhang Y, Liu G, Ungles C, et al.
Diabetes
. 2006 Dec;
56(1):96-106.
PMID: 17192470
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are key signaling molecules for pancreas development. Although FGFR3 is a crucial developmental gene, acting as a negative regulator of bone formation,...
9.
Liu G, Arnaud-Dabernat S, Kritzik M, Kayali A, Zhang Y, Sarvetnick N
Endocrine
. 2006 Dec;
30(1):103-12.
PMID: 17185798
Gut peptide YY (PYY) plays an important role in regulating metabolism and is expressed during the ontogeny of the pancreas. However, its biological role during endocrine cell formation is not...
10.
Hua H, Zhang Y, Dabernat S, Kritzik M, Dietz D, Sterling L, et al.
J Biol Chem
. 2006 Mar;
281(19):13574-13580.
PMID: 16547003
Inhibitor of DNA binding (Id) proteins bind to and inhibit the function of basic helix-loop-helix (bHLH) transcription factors including those that regulate pancreatic development. Moreover, bone morphogenetic proteins (BMPs) regulate...