Yoshitaka Takahashi
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Explore the profile of Yoshitaka Takahashi including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
478
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Recent Articles
1.
Dote S, Shiwaku E, Kohno E, Fujii R, Mashimo K, Morimoto N, et al.
Int J Clin Oncol
. 2023 Jun;
28(8):1054-1062.
PMID: 37261583
Background: The association between prior bevacizumab (BEV) therapy and ramucirumab (RAM)-induced proteinuria is not known. We aimed to investigate this association in patients with metastatic colorectal cancer (mCRC). Methods: mCRC...
2.
Tsutsumi M, Hiradate S, Yokogawa M, Yamakita E, Inoue M, Takahashi Y
PLoS One
. 2022 Nov;
17(11):e0275808.
PMID: 36449453
Restoration of species-rich semi-natural grassland requires not only a seed source but also appropriate soil properties. In Europe, approximately 10 years are required for the properties of fertilized soils to...
3.
Tsukayama I, Kawakami Y, Tamenobu A, Toda K, Maruoka S, Nagasaki Y, et al.
Free Radic Biol Med
. 2022 Oct;
193(Pt 1):1-8.
PMID: 36183930
As pro-inflammatory lipid mediators, leukotrienes have pathophysiological activities in several inflammatory diseases, including psoriasis. In the biosynthesis of leukotrienes from arachidonic acid, 5-lipoxygenase catalyzes the first two steps. In the...
4.
Nagasaki Y, Kawai E, Maruoka S, Osumi M, Tsukayama I, Kawakami Y, et al.
Biochem Biophys Res Commun
. 2022 Sep;
630:84-91.
PMID: 36152349
Milk lipids are an important energy source for infants, but the composition of milk lipids has not yet been clarified in detail. In this study, we analyzed free fatty acids...
5.
Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, et al.
Prostaglandins Other Lipid Mediat
. 2021 Jul;
156:106580.
PMID: 34252545
Using a wild yam (Dioscorea japonica), we previously found novel anti-inflammatory and anti-carcinogenic effects via the downregulation of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1. One of the substances...
6.
Mitsui T, Makino S, Tamiya G, Sato H, Kawakami Y, Takahashi Y, et al.
J Hum Genet
. 2021 Feb;
66(8):753-759.
PMID: 33564083
The arachidonic acid (AA) cascade plays a significant role in platelet aggregation. AA released from membrane phospholipids is metabolized by cyclooxygenase (COX) pathway to thromboxane A (TXA) or by 12S-lipoxygenase...
7.
Mori Y, Kawakami Y, Kanzaki K, Otsuki A, Kimura Y, Kanji H, et al.
J Biochem
. 2020 Jun;
168(5):455-463.
PMID: 32492133
A role of 12-lipoxygenase in the progression of non-alcoholic steatohepatitis (NASH) is suggested, although the underlying mechanism is not entirely understood. The catalytic activity of 12S-lipoxygenase that was hardly observed...
8.
Toda K, Tsukayama I, Nagasaki Y, Konoike Y, Tamenobu A, Ganeko N, et al.
Arch Biochem Biophys
. 2020 Mar;
689:108307.
PMID: 32112739
5-lipoxygenase is a key enzyme in the synthesis of leukotrienes from arachidonic acid. The produced leukotrienes are involved in inflammatory diseases including psoriasis, asthma, and atherosclerosis. A suitable 5-lipoxygenase inhibitor...
9.
Toda K, Ueyama M, Tanaka S, Tsukayama I, Mega T, Konoike Y, et al.
Biosci Biotechnol Biochem
. 2019 Dec;
84(4):757-763.
PMID: 31868102
Prostaglandin E (PGE), which is a potent pro-inflammatory lipid mediator, is biosynthesized from arachidonic acid by cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). Non-steroidal anti-inflammatory drugs (NSAIDs) are used clinically...
10.
Kawakami Y, Otsuki A, Mori Y, Kanzaki K, Suzuki-Yamamoto T, Fang D, et al.
Molecules
. 2019 Jan;
24(2).
PMID: 30650646
We have previously found two novel monoterpene glycosides, liguroside A and liguroside B, with an inhibitory effect on the catalytic activity of the enzyme leukocyte-type 12-lipoxygenase in the Qing Shan...