Yoshihiko Ohyama
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Explore the profile of Yoshihiko Ohyama including associated specialties, affiliations and a list of published articles.
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18
Citations
311
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Recent Articles
1.
Ohara M, Ohyama Y
Curr Drug Metab
. 2013 Dec;
15(1):37-47.
PMID: 24328691
At present, dietary polyphenols are popular with consumers because regular consumption of polyphenol-rich foods is likely to be beneficial for human health. However, administrated polyphenols are extensively metabolized in the...
2.
Hara K, Ohara M, Hayashi I, Hino T, Nishimura R, Iwasaki Y, et al.
Eur J Oral Sci
. 2012 Mar;
120(2):132-9.
PMID: 22409219
Green tea is a popular drink throughout the world, and it contains various components, including the green tea polyphenol (-)-epigallocatechin gallate (EGCG). Tea interacts with saliva upon entering the mouth,...
3.
Nishimura Y, Okamoto Y, Ikunaka M, Ohyama Y
Chem Pharm Bull (Tokyo)
. 2011 Dec;
59(12):1458-66.
PMID: 22130366
A mixture of alkyl 1,4-dihydro-2-methylthio-4,4,6-trisubstituted pyrimidine-5-carboxylate 1 and its tautomeric isomer, alkyl 1,6-dihydro-2-methylthio-4,6,6-trisubstituted pyrimidine-5-carboxylate 2 is synthesized by the Atwal-Biginelli cyclocondensation reaction of S-methylisothiourea hemisulfate salt 3 with 2-(gem-disubstituted)methylene-3-oxoesters 4...
4.
Aiba I, Yamasaki T, Shinki T, Izumi S, Yamamoto K, Yamada S, et al.
Steroids
. 2006 Jul;
71(10):849-56.
PMID: 16842832
vitamin D is 25-hydroxylated in the liver, before being activated by 1alpha-hydroxylation in the kidney. Recently, the rat cytochrome P450 2J3 (CYP2J3) has been identified as a principal vitamin D...
5.
Ohyama Y, Meaney S, Heverin M, Ekstrom L, Brafman A, Shafir M, et al.
J Biol Chem
. 2005 Dec;
281(7):3810-20.
PMID: 16321981
Mammalian CNS contains a disproportionally large and remarkably stable pool of cholesterol. Despite an efficient recycling there is some requirement for elimination of brain cholesterol. Conversion of cholesterol into 24S-hydroxycholesterol...
6.
Ohyama Y, Yamasaki T
Front Biosci
. 2004 Sep;
9:3007-18.
PMID: 15353333
Vitamin D3 plays a central role in calcium and phosphate homeostasis and is essential for the proper development and maintenance of bone. To exert its biological activities, vitamin D3 has...
7.
Mohsin Ali M, Kurisu S, Yoshioka Y, Terato H, Ohyama Y, Kubo K, et al.
J Radiat Res
. 2004 Aug;
45(2):229-37.
PMID: 15304965
Ionizing radiation generates diverse DNA lesions that differentially induce cell death and mutations. In the present study, calf thymus DNA (400 microg/ml) and HeLa cells were irradiated by (60)Co gamma-rays,...
8.
Yamasaki T, Izumi S, Ide H, Ohyama Y
J Biol Chem
. 2004 Mar;
279(22):22848-56.
PMID: 15026419
Vitamin D3 requires the 25-hydroxylation in the liver and the subsequent 1alpha-hydroxylation in the kidney to exert its biological activity. Vitamin D3 25-hydroxylation is hence an essential modification step for...
9.
Katafuchi A, Matsuo A, Terato H, Ohyama Y, Ide H
Nucleic Acids Res Suppl
. 2003 Sep;
(3):269-70.
PMID: 14510484
5-Hydroxyuracil (HOU) and 5-hydroxycytosine (HOC) are major oxidative lesions of cytosine with mutagenic potentials. Therefore, HOU and HOC need to be removed from DNA to avoid mutation. In this study,...
10.
Masaoka A, Matsubara M, Tanaka T, Terato H, Ohyama Y, Kubo K, et al.
Nucleic Acids Res Suppl
. 2003 Sep;
(3):263-4.
PMID: 14510481
Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA glycosylase (UDG). However, the subsequent studies have shown conflicting results about the substrate...