Yoshihiko Hirohashi
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Explore the profile of Yoshihiko Hirohashi including associated specialties, affiliations and a list of published articles.
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223
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2985
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Recent Articles
1.
Kashiwagi H, Shigehara K, Kubo T, Hirohashi Y, Mariya T, Matsuo K, et al.
Med Mol Morphol
. 2025 Mar;
PMID: 40082293
Placenta accreta spectrum (PAS) is a serious disease leading to complications and maternal death. The objective of the study was to characterize the placental villi and blood vessels of PAS...
2.
Sasaki K, Murata K, Minowa T, Shijubou N, Kobayashi H, Nakatsugawa M, et al.
Biochem Biophys Rep
. 2025 Mar;
41:101946.
PMID: 40046256
Inducing antigen peptide-specific cytotoxic T cells is challenging, partly due to the difficulty of maintaining the quality of antigen-presenting cells, such as dendritic cells. Consequently, artificial antigen-presenting cells (aAPCs) derived...
3.
Kato H, Tsukahara T, Murata K, Nishikata H, Mizue Y, Sasaya T, et al.
Cancer Immunol Immunother
. 2025 Mar;
74(4):133.
PMID: 40035876
The development of effective immunotherapies for solid tumors remains a significant challenge. In previous studies, we identified PVT1, a long non-coding RNA, with the peptide HF10 derived from PVT1, presented...
4.
Moniwa K, Tokita S, Sumi T, Saijo H, Sugita S, Arioka K, et al.
Cancer Sci
. 2025 Feb;
PMID: 39989216
Tumors can evade host immune surveillance by compromising the intracellular antigen processing machinery (APM), such as beta 2 macroglobulin (β2m) or the transporter associated with antigen processing (TAP). Defects in...
5.
Kikuchi N, Hatanaka S, Kubo T, Kamekura R, Kanda M, Kakuki T, et al.
Immunol Med
. 2025 Feb;
:1-7.
PMID: 39902902
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. It affects various organs, including the pancreas...
6.
Fusagawa M, Tokita S, Murata K, Mariya T, Umemoto M, Sugita S, et al.
Cancer Immunol Res
. 2024 Dec;
13(2):171-184.
PMID: 39655805
Tumor-reactive CD4+ T cells often accumulate in the tumor microenvironment (TME) in human cancer, but their functions and roles in antitumor responses remain elusive. Here, we investigated the immunopeptidome of...
7.
Minowa T, Murata K, Mizue Y, Murai A, Nakatsugawa M, Sasaki K, et al.
Sci Transl Med
. 2024 Dec;
16(776):eadk8832.
PMID: 39630887
Acral lentiginous melanoma (ALM) is the most common melanoma subtype in non-Caucasians. Despite advances in cancer immunotherapy, current immune checkpoint inhibitors remain unsatisfactory for ALM. Hence, we conducted comprehensive immune...
8.
Hori K, Yamada S, Murata K, Miyata H, Mizue Y, Murai A, et al.
Hum Vaccin Immunother
. 2024 Nov;
20(1):2414542.
PMID: 39539024
Adoptive T cell therapy, using T cell receptor-engineered T (TCR-T) cells and chimeric antigen receptor T (CAR-T) cells, is a potent immunotherapy option. Bladder cancer is a prevalent urological malignancy,...
9.
Matsumoto S, Tsujikawa T, Tokita S, Mohamed Bedeir M, Matsuo K, Hata F, et al.
Oncoimmunology
. 2024 Nov;
13(1):2404665.
PMID: 39508845
Neoantigen-reactive CD4 T cells play a key role in the anti-tumor immune response. However, the majority of epithelial tumors are negative for HLA class II (HLA-II) surface expression, and less...
10.
Kitagawa M, Kaguchi J, Someya M, Fukushima Y, Hasegawa T, Tsuchiya T, et al.
Cancer Diagn Progn
. 2024 Nov;
4(6):789-796.
PMID: 39502617
Background/aim: Radiotherapy (RT) for advanced oropharyngeal cancer (OPC) is effective, especially when combined with chemotherapy (CRT). However, its success can vary depending on factors, such as tumor stage, HPV infection...