Yoon Kwang Lee
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Explore the profile of Yoon Kwang Lee including associated specialties, affiliations and a list of published articles.
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16
Citations
507
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Recent Articles
1.
Hardwick J, Song B, Rote P, Leahy C, Lee Y, Wolf A, et al.
Front Physiol
. 2025 Feb;
15:1497297.
PMID: 39959811
Introduction: Metabolic-dysfunction-associated steatosis liver disease (MASLD) is a progressive liver disease from simple steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic liver diseases (CLDs) can lead to portal hypertension, which...
2.
Lee Y, Park J, Lee M, Hardwick J
Liver Res
. 2019 Jun;
2(4):209-215.
PMID: 31245168
Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation and proliferation of...
3.
Park J, Lee M, Kim S, Zhang Y, Hardwick J, Lee Y
Hepatol Commun
. 2018 Feb;
1(10):1085-1098.
PMID: 29404444
Peroxisome proliferator-activated receptor gamma (PPARγ) is a master regulator for white adipocyte differentiation and lipid storage. The increased level of hepatic PPARγ2 isoform reprograms liver for lipid storage and causes...
4.
Jadhav K, Xu Y, Xu Y, Li Y, Xu J, Zhu Y, et al.
Mol Metab
. 2018 Jan;
9:131-140.
PMID: 29361497
Objectives: Activation of the bile acid (BA) receptors farnesoid X receptor (FXR) or G protein-coupled bile acid receptor (GPBAR1; TGR5) improves metabolic homeostasis. In this study, we aim to determine...
5.
Akinrotimi O, Riessen R, VanDuyne P, Park J, Lee Y, Wong L, et al.
Hepatology
. 2017 Jun;
66(6):1854-1865.
PMID: 28586124
Conclusion: These data suggest that Fxr and Shp inactivation may be beneficial to combat diet-induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease. (Hepatology 2017;66:1854-1865).
6.
Palmisano B, Le T, Zhu L, Lee Y, Stafford J
J Lipid Res
. 2016 Jun;
57(8):1541-51.
PMID: 27354419
Elevated plasma TGs increase risk of cardiovascular disease in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood. Here we explore the role of cholesteryl...
7.
Park J, Lee M, Mifflin R, Lee Y
Am J Physiol Gastrointest Liver Physiol
. 2016 Mar;
310(10):G799-807.
PMID: 26968209
Deficiency of the orphan nuclear hormone receptor small heterodimer partner (SHP, NR0B2) protects mice from diet-induced hepatic steatosis, in part, via repression of peroxisome proliferator-activated receptor (PPAR)-γ2 (Pparg2) gene expression....
8.
Ahn H, Kim H, Kim Y, Kim M, Ohn J, Chung S, et al.
Endocrinol Metab (Seoul)
. 2015 Oct;
30(4):584-92.
PMID: 26485468
Background: Expression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP...
9.
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee Y, et al.
Curr Mol Pharmacol
. 2015 Aug;
10(3):226-236.
PMID: 26278388
Lipin-1, a mammalian phosphatidic acid phosphatase (PAP), is a bi-functional molecule involved in various signaling pathways via its function as a PAP enzyme in the triglyceride synthesis pathway and in...
10.
Tseng H, Park Y, Lee Y, Moore D
J Biomed Sci
. 2015 May;
22:30.
PMID: 25951943
Background: Small heterodimer partner (SHP, NR0B2) is involved in diverse metabolic pathways, including hepatic bile acid, lipid and glucose homeostasis, and has been implicated in effects on the peroxisome proliferator-activated...