Yongxin Zhu
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Explore the profile of Yongxin Zhu including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
211
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Recent Articles
21.
Zheng J, Mehl J, Zhu Y, Xin B, Olah T
Bioanalysis
. 2014 Apr;
6(6):859-79.
PMID: 24702115
As more protein therapeutics enter the drug-discovery pipeline, the traditional ligand-binding assay (LBA) faces additional challenges to meet the rapid and diverse bioanalytical needs in the early drug-discovery stage. The...
22.
Codd E, Ma J, Zhang S, Stone Jr D, Colburn R, Brandt M, et al.
Pharmacol Biochem Behav
. 2010 May;
96(2):130-5.
PMID: 20438745
Discovered as part of an effort to identify delta opioid (DOPr or DOR) agonist analgesics, JNJ-20788560 and JNJ-39204880 exhibited high DOR affinity, with K(i) values of 1.7 and 2.0nM, respectively,...
23.
Janle E, Morre D, Morre D, Zhou Q, Zhu Y
J Diet Suppl
. 2009 Nov;
5(3):248-63.
PMID: 19885387
Catechins are a major constituent of green tea. For green tea to have cancer therapeutic benefit, catechin concentrations in the range of 100 nM are required continuously until apoptosis (programmed...
24.
Wiseman J, Ifa D, Zhu Y, Kissinger C, Manicke N, Kissinger P, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(47):18120-5.
PMID: 18697929
Ambient ionization methods for MS enable direct, high-throughput measurements of samples in the open air. Here, we report on one such method, desorption electrospray ionization (DESI), which is coupled to...
25.
Janle E, Portocarrero C, Zhu Y, Zhou Q
J Herb Pharmacother
. 2006 Mar;
5(3):55-65.
PMID: 16520298
There have been some claims that green tea reduces weight and lowers blood glucose in diabetes. Intraperitoneal injections of green tea catechins in diabetic rats have shown beneficial effects. To...
26.
Zhu Y, Chiang H, Wulster-Radcliffe M, Hilt R, Wong P, Kissinger C, et al.
J Pharm Biomed Anal
. 2005 May;
38(1):119-25.
PMID: 15907629
A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of carbamazepine and its main metabolite carbamazepine 10,11-epoxide in rat plasma is described. The method consists of a liquid-liquid...
27.
Zhou Q, Zhu Y, Chiang H, Yagiz K, Morre D, Morre D, et al.
Phytochem Anal
. 2004 May;
15(2):117-20.
PMID: 15116943
A sensitive multi-channel HPLC-electrochemical (EC) method has been developed to determine the vanilloid content in the complex Capsicum annuum extract Capsibiol. Chromatographic separation was achieved within 10 min using a...
28.
Xie F, Bruntlett C, Zhu Y, Kissinger C, Kissinger P
Anal Sci
. 2003 May;
19(4):479-85.
PMID: 12725380
The preclinical bioanalytical process with animal models begins with sampling biological fluids and tissue. The goal is to understand oral absorption kinetics, distribution, metabolism, excretion, blood brain barrier penetration, drug-drug...
29.
Zhang T, Zhu Y, Gunaratna C
J Chromatogr B Analyt Technol Biomed Life Sci
. 2002 Oct;
780(2):371-9.
PMID: 12401364
A rapid quantitative assay method, developed by combining fast gradient liquid chromatography and electrospray ionization-ion trap mass spectrometry, is described for the simultaneous determination of CYP450 probe substrate metabolites (4-aminophenol...
30.
Tian F, Zhu Y, Long H, Cregor M, Xie F, Kissinger C, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2002 May;
772(1):173-7.
PMID: 12016029
Daidzin, a soy-derived biologically active natural product, has been reported to inhibit mitochondrial aldehyde dehydrogenase and suppress ethanol intake. This paper describes a method for the determination of daidzin in...