YongTian Liang
Overview
Explore the profile of YongTian Liang including associated specialties, affiliations and a list of published articles.
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10
Citations
1311
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Recent Articles
1.
Fei L, Liang Y, Kintscher U, Sigrist S
Redox Biol
. 2024 Dec;
79():103454.
PMID: 39642596
Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic...
2.
Hofer S, Daskalaki I, Bergmann M, Friscic J, Zimmermann A, Mueller M, et al.
Nat Cell Biol
. 2024 Aug;
26(9):1571-1584.
PMID: 39117797
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and...
3.
Jang W, Puchkov D, Samso P, Liang Y, Nadler-Holly M, Sigrist S, et al.
Science
. 2022 Dec;
378(6625):eabq5209.
PMID: 36520888
Cells respond to fluctuating nutrient supply by adaptive changes in organelle dynamics and in metabolism. How such changes are orchestrated on a cell-wide scale is unknown. We show that endosomal...
4.
Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, et al.
EMBO Mol Med
. 2022 Apr;
14(5):e13952.
PMID: 35373908
Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer's disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic...
5.
Hofer S, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, et al.
Autophagy
. 2021 Jun;
17(8):2037-2039.
PMID: 34105442
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some...
6.
Liang Y
Histol Histopathol
. 2021 May;
36(10):1007-1019.
PMID: 34032272
Complex neural and brain functions are executed through structural and functional alterations of synapses and neurons. Neuronal compartmentalization requires neurons to allocate mitochondria and proteins in a spatiotemporal manner to...
7.
Liang Y, Piao C, Beuschel C, Toppe D, Kollipara L, Bogdanow B, et al.
Cell Rep
. 2021 Apr;
35(2):108941.
PMID: 33852845
Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown...
8.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
9.
Liang Y
Cells
. 2019 Jan;
8(1).
PMID: 30634508
Protein homeostasis (proteostasis) is crucial to the maintenance of neuronal integrity and function. As the contact sites between neurons, synapses rely heavily on precisely regulated protein-protein interactions to support synaptic...
10.
Liang Y, Sigrist S
Curr Opin Neurobiol
. 2017 Dec;
48:113-121.
PMID: 29274917
The maintenance of neuronal homeostasis is severely threatened by aging, probably partially due to compromised autophagic clearance. Hence, rejuvenating autophagy in aging neurons is considered a promising strategy to restore...