Yonggui Chi
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Explore the profile of Yonggui Chi including associated specialties, affiliations and a list of published articles.
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12
Citations
103
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Recent Articles
1.
Chen B, Long Q, Zhao Y, Wu Y, Ge S, Wang P, et al.
J Agric Food Chem
. 2019 Jun;
67(25):6962-6969.
PMID: 31150235
Target validation of current drugs remains the major challenge for target-based drug discovery, especially for agrochemical discovery. The bactericide 0 represents a novel lead structure and has shown potent efficacy...
2.
Guo L, Chi Y, Almeida A, Guzei I, Parker B, Gellman S
J Am Chem Soc
. 2009 Nov;
131(44):16018-20.
PMID: 19886693
A highly stereoselective synthesis of novel cyclically constrained gamma-amino acid residues is presented. The key step involves organocatalytic Michael addition of an aldehyde to 1-nitrocyclohexene. After aldehyde reduction, this approach...
3.
Scroggins S, Chi Y, Frechet J
Angew Chem Int Ed Engl
. 2009 Aug;
49(13):2393-6.
PMID: 19688803
No abstract available.
4.
Chi Y, Scroggins S, Boz E, Frechet J
J Am Chem Soc
. 2008 Nov;
130(51):17287-9.
PMID: 19032033
A fundamental chemoselectivity challenge that remains intrinsically unsolved in aldol-type reactions is the suppression of self-aldol reactions with enolizable aldehydes in reactions such as cross-aldol processes. Contrasting with the usual...
5.
Chi Y, Scroggins S, Frechet J
J Am Chem Soc
. 2008 Apr;
130(20):6322-3.
PMID: 18433122
Non-interpenetrating star polymer catalysts designed to mimic the site isolation characteristics of enzymes enable the one-pot combination of multiple otherwise incompatible catalysts for asymmetric cascade reactions that involve iminium, enamine,...
6.
Chi Y, Guo L, Kopf N, Gellman S
J Am Chem Soc
. 2008 Apr;
130(17):5608-9.
PMID: 18386925
Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed by (S)-diphenylprolinol silyl ether provides beta-substituted-delta-nitroalcohols in nearly optically pure form (96-99% ee). The Michael adducts bear a single substituent adjacent...
7.
Chi Y, English E, Pomerantz W, Seth Horne W, Joyce L, Alexander L, et al.
J Am Chem Soc
. 2007 Apr;
129(18):6050-5.
PMID: 17439122
Proline-catalyzed diastereoselective aminomethylation of aldehydes using a chiral iminium ion, generated from a readily prepared precursor, provides alpha-substituted-beta-amino aldehydes with 85:15 to 90:10 dr. The alpha-substituted-beta-amino aldehydes can be reduced...
8.
Chi Y, Gellman S
J Am Chem Soc
. 2006 May;
128(21):6804-5.
PMID: 16719457
Organocatalytic Mannich addition of aldehydes to a formaldehyde-derived iminium species catalyzed by proline-derived chiral pyrrolidines provides beta-amino aldehydes with >/=90% ee. Mechanistic analysis of the proline-catalyzed reactions suggests that non-hydrogen-bonded...
9.
Chi Y, Gellman S
Org Lett
. 2005 Sep;
7(19):4253-6.
PMID: 16146400
[reaction: see text] Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst...
10.
Peelen T, Chi Y, Gellman S
J Am Chem Soc
. 2005 Aug;
127(33):11598-9.
PMID: 16104725
An enantioselective intermolecular Michael addition of aldehydes to enones catalyzed by imidazolidinones has been achieved. Chemoselectivity (Michael addition vs aldol) can be controlled through judicious choice of hydrogen-bond-donating cocatalysts. The...