Yong S Chang
Overview
Explore the profile of Yong S Chang including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
845
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0
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Recent Articles
11.
Ordonez A, Weinstein E, Bambarger L, Saini V, Chang Y, DeMarco V, et al.
J Nucl Med
. 2016 Sep;
58(1):144-150.
PMID: 27635025
Methods: We systematically screened 961 random radiolabeled molecules in silico as substrates for essential metabolic pathways in bacteria, followed by in vitro uptake in representative bacteria-Staphylococcus aureus, Escherichia coli, Pseudomonas...
12.
Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, et al.
Cancer Res
. 2016 Jan;
76(2):480-90.
PMID: 26744529
Elevated levels of the proinflammatory cytokine IL6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL6 and its receptor have been developed for chronic inflammatory disease, but...
13.
Chang Y, Graves B, Guerlavais V, Tovar C, Packman K, To K, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(36):E3445-54.
PMID: 23946421
Stapled α-helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we report a potent and selective dual inhibitor of MDM2 and MDMX,...
14.
Gao J, Chang Y, Jallal B, Viner J
Cancer Res
. 2012 Jan;
72(1):3-12.
PMID: 22215692
Insulin-like growth factors (IGF) are polypeptide hormones with potent anabolic and mitogenic effects that regulate cell growth and differentiation. Dysregulation of the IGF axis has been well documented in the...
15.
Petrul H, Schatz C, Kopitz C, Adnane L, McCabe T, Trail P, et al.
Mol Cancer Ther
. 2011 Dec;
11(2):340-9.
PMID: 22147747
Carbonic anhydrase IX (CAIX) is a cell surface glycoprotein that is expressed in many different tumors and yet restricted in normal tissues to the gastrointestinal tract. It is upregulated by...
16.
Gao J, Chesebrough J, Cartlidge S, Ricketts S, Incognito L, Veldman-Jones M, et al.
Cancer Res
. 2011 Jan;
71(3):1029-40.
PMID: 21245093
Insulin-like growth factors (IGF), IGF-I and IGF-II, are small polypeptides involved in regulating cell proliferation, survival, differentiation, and transformation. IGF activities are mediated through binding and activation of IGF-1R or...
17.
Chang Y, Adnane J, Trail P, Levy J, Henderson A, Xue D, et al.
Cancer Chemother Pharmacol
. 2006 Dec;
59(5):561-74.
PMID: 17160391
Purpose: New research findings have revealed a key role for vascular endothelial growth factor (VEGF) in the stimulation of angiogenesis in clear cell renal carcinoma (RCC) which is a highly...