Yong-Quan Li
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Explore the profile of Yong-Quan Li including associated specialties, affiliations and a list of published articles.
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106
Citations
1046
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Recent Articles
11.
Gao W, Fang J, Zhu C, Xu W, Lyu Z, Chan X, et al.
Microbiol Spectr
. 2023 May;
11(3):e0038023.
PMID: 37154757
DNA methylation is a defense that microorganisms use against extreme environmental stress, and improving resistance against environmental stress is essential for industrial actinomycetes. However, research on strain optimization utilizing DNA...
12.
Xu W, Sun C, Gao W, Scharf D, Zhu C, Bu Q, et al.
Protein Sci
. 2023 Mar;
32(4):e4617.
PMID: 36882943
The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional...
13.
Fang J, Gao W, Xu W, Lyu Z, Ma L, Luo S, et al.
Synth Syst Biotechnol
. 2022 Jul;
7(4):1013-1023.
PMID: 35801092
Despite numerous studies on transcriptional level regulation by single genes in drug producing , the global regulation based on epigenetic modification is not well explored. N4-methylcytosine (m4C), an abundant epigenetic...
14.
Li R, Liu X, Zhang M, Xu W, Li Y, Chen X
J Fungi (Basel)
. 2022 May;
8(5).
PMID: 35628765
As a potential protein kinase C inhibitor, the fungus metabolite balanol has become more attractive in recent decades. In our previous work, we revealed its biosynthetic pathway through overexpression of...
15.
Liu X, Wang J, Chen X, Liu Y, Li Y
Front Microbiol
. 2022 May;
13:902990.
PMID: 35620094
The emergence of drug resistance highlights the importance of new drug discovery. Microbial secondary metabolites encoded in biosynthetic gene clusters (BGCs) are a prolific source of drugs, whereas most of...
16.
Lyu Z, Bu Q, Fang J, Zhu C, Xu W, Ma L, et al.
Front Microbiol
. 2022 May;
13:872397.
PMID: 35509317
Daptomycin is a cyclic lipopeptide antibiotic with a significant antibacterial action against antibiotic-resistant Gram-positive bacteria. Despite numerous attempts to enhance daptomycin yield throughout the years, the production remains unsatisfactory. This...
17.
Xu W, Fang J, Bu Q, Lyu Z, Zhu C, Sun C, et al.
Appl Microbiol Biotechnol
. 2022 Apr;
106(8):3103-3112.
PMID: 35389068
Daptomycin is a new lipopeptide antibiotic for treatment of severe infection caused by multi-drug-resistant bacteria, but its production cost remains high currently. Thus, it is very important to improve the...
18.
Xia T, Chen X, Liu Y, Scharf D, Zhao Q, Li Y
Microb Biotechnol
. 2022 Feb;
15(6):1852-1866.
PMID: 35213090
The metabolic flux of fatty acyl-CoAs determines lipopeptide biosynthesis efficiency, because acyl donor competition often occurs from polyketide biosynthesis and homologous pathways. We used A40926B0 as a model to investigate...
19.
Xu Y, Liu X, Chen X, Li Y
Molecules
. 2022 Feb;
27(3).
PMID: 35164125
The azoxy compounds with an intriguing chemical bond [-N=N(-O)-] are known to have broad applications in many industries. Our previous work revealed that a nonheme diiron N-oxygenase AzoC catalyzed the...
20.
Liang Z, Lei J, Zhang H, Li Y, Zhang B
Mitochondrial DNA B Resour
. 2021 Dec;
7(1):19-20.
PMID: 34912957
(Annonaceae) is endemic to China, this plant has high medicinal value and broad application prospect. In this study, we assembled and systematically analyzed the chloroplast genome of on the basis...