Xin-Ai Chen
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Explore the profile of Xin-Ai Chen including associated specialties, affiliations and a list of published articles.
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33
Citations
241
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Recent Articles
1.
Gao W, Ma L, Li M, Xu W, Sun C, Zhao Q, et al.
Metab Eng
. 2024 Nov;
87:1-10.
PMID: 39542082
We propose here that acylation modification of actinomycete proteins is a restrictive system that limits the excessive synthesis of secondary metabolites, its mechanism has not been clearly elucidated before. We...
2.
Zhou E, Chen X, Zhou M, Xu L, Wang D, Shen H, et al.
Infect Genet Evol
. 2024 Feb;
120:105575.
PMID: 38403034
Mucormycosis is receiving much more attention because of its high morbidity and extremely high mortality rate in immunosuppressed populations. In this study, we isolated a Cunnignhamella bertholletiae Z2 strain from...
3.
Liu X, Li R, Zeng Q, Li Y, Chen X
Microorganisms
. 2023 Oct;
11(10).
PMID: 37894236
Asperpyridone A represents an unusual class of pyridone alkaloids with demonstrated potential for hypoglycemic activity, primarily by promoting glucose consumption in HepG2 cells. Trichodin A, initially isolated from the marine...
4.
Zhu C, Zhao X, Lyu Z, Gao W, Zhao Q, Chen X, et al.
J Appl Microbiol
. 2023 Oct;
134(10).
PMID: 37873659
Aims: We evaluated whether the randomness of mutation breeding can be regulated through a double-reporter system. We hope that by establishing a new precursor feeding strategy, the production capacity of...
5.
Chen H, Zhang X, Wu Q, Zhao Q, Chen X, Li Y
J Appl Microbiol
. 2023 Jul;
134(7).
PMID: 37429605
Aims: Study of the effect of isoleucine on the biosynthesis of FK506 and modification of its producing strain to improve the production of FK506. Methods And Results: Metabolomics analysis was...
6.
Fang J, Gao W, Xu W, Lyu Z, Ma L, Luo S, et al.
Synth Syst Biotechnol
. 2022 Jul;
7(4):1013-1023.
PMID: 35801092
Despite numerous studies on transcriptional level regulation by single genes in drug producing , the global regulation based on epigenetic modification is not well explored. N4-methylcytosine (m4C), an abundant epigenetic...
7.
Li R, Liu X, Zhang M, Xu W, Li Y, Chen X
J Fungi (Basel)
. 2022 May;
8(5).
PMID: 35628765
As a potential protein kinase C inhibitor, the fungus metabolite balanol has become more attractive in recent decades. In our previous work, we revealed its biosynthetic pathway through overexpression of...
8.
Liu X, Wang J, Chen X, Liu Y, Li Y
Front Microbiol
. 2022 May;
13:902990.
PMID: 35620094
The emergence of drug resistance highlights the importance of new drug discovery. Microbial secondary metabolites encoded in biosynthetic gene clusters (BGCs) are a prolific source of drugs, whereas most of...
9.
Lyu Z, Bu Q, Fang J, Zhu C, Xu W, Ma L, et al.
Front Microbiol
. 2022 May;
13:872397.
PMID: 35509317
Daptomycin is a cyclic lipopeptide antibiotic with a significant antibacterial action against antibiotic-resistant Gram-positive bacteria. Despite numerous attempts to enhance daptomycin yield throughout the years, the production remains unsatisfactory. This...
10.
Xia T, Chen X, Liu Y, Scharf D, Zhao Q, Li Y
Microb Biotechnol
. 2022 Feb;
15(6):1852-1866.
PMID: 35213090
The metabolic flux of fatty acyl-CoAs determines lipopeptide biosynthesis efficiency, because acyl donor competition often occurs from polyketide biosynthesis and homologous pathways. We used A40926B0 as a model to investigate...