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Yong-Ming Yu

Explore the profile of Yong-Ming Yu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 54
Citations 623
Followers 0
Related Specialties
Emergency Medicine
General Surgery
Physiology
Top 10 Co-Authors
Ronald G Tompkins
Alan J Fischman
Masao Kaneki
Edward A Carter
Vernon R Young
Ali A Bonab
Gaofeng Zhao
Xiao-Ming Lu
J A Jeevendra Martyn
Wenjun Z Martini
Published In
J Burn Care Res
Am J Physiol Endocrinol Metab
Surgery
Shock
Int J Burns Trauma
Affiliations
Soon will be listed here.
Recent Articles
11.
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, et al.
Sci Rep . 2017 Jul; 7(1):6618. PMID: 28747716
Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Nonetheless,...
12.
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53
Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, et al.
PLoS One . 2017 Jan; 12(1):e0170391. PMID: 28099528
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting. We and others have shown that...
13.
Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model
Fei Z, Young V, Lu X, Rhodes A, Tompkins R, Fischman A, et al.
Burns Trauma . 2016 Aug; 1(2):87-94. PMID: 27574630
Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the...
14.
Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2
Inoue Y, Yu Y, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, et al.
Crit Care Med . 2015 Oct; 44(5):e241-52. PMID: 26509319
Objectives: Innate immune dysfunction after major burn injuries increases the susceptibility to organ failure. Lipid mediators of inflammation resolution, e.g., resolvin D2, have been shown recently to restore neutrophil functionality...
15.
Tight Glycemic Control With Insulin Does Not Affect Skeletal Muscle Degradation During the Early Postoperative Period Following Pediatric Cardiac Surgery
Fisher J, Sparks E, Khan F, Alexander J, Asaro L, Wypij D, et al.
Pediatr Crit Care Med . 2015 Apr; 16(6):515-21. PMID: 25850865
Objective: Critical illness is associated with significant catabolism, and persistent protein loss correlates with increased morbidity and mortality. Insulin is a potent anticatabolic hormone; high-dose insulin decreases skeletal muscle protein...
16.
Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle
Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu Y, Fischman A, et al.
PLoS One . 2015 Jan; 10(1):e0116633. PMID: 25594415
Objective: Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a posttranslational lipid...
17.
Simvastatin reduces burn injury-induced splenic apoptosis via downregulation of the TNF-α/NF-κB pathway
Zhao G, Yu Y, Kaneki M, Bonab A, Tompkins R, Fischman A
Ann Surg . 2014 Jun; 261(5):1006-12. PMID: 24950285
Objective: Recent studies have suggested that epidermal burn injuries are associated with inflammation and immune dysfunction. Simvastatin has been shown to possess potent anti-inflammatory properties. Thus, we hypothesized that simvastatin...
18.
Isotopic study of L-Arginine kinetics in the lung during pseudomonas sepsis in an ovine model
Xu H, Watson D, Yu Y, Traber D, Fischer S, Nichols J, et al.
Int J Burns Trauma . 2014 Mar; 4(1):31-9. PMID: 24624312
Unlabelled: The objective of the study is to investigate how L-Arginine pulmonary metabolism is altered in response Pseudomonas aeruginosa (P. aeruginosa) induced septic conditions using an ovine model. Methods: Seven...
19.
Membrane potential-dependent uptake of 18F-triphenylphosphonium--a new voltage sensor as an imaging agent for detecting burn-induced apoptosis
Zhao G, Yu Y, Shoup T, Elmaleh D, Bonab A, Tompkins R, et al.
J Surg Res . 2014 Mar; 188(2):473-9. PMID: 24582214
Background: Mitochondrial dysfunction has been closely related to many pathologic processes, such as cellular apoptosis. Alterations in organelle membrane potential are associated with mitochondrial dysfunction. A fluorine-18 labeled phosphonium compound:...
20.
Variability of resting energy expenditure in infants and young children with intestinal failure-associated liver disease
Duro D, Mitchell P, Mehta N, Bechard L, Yu Y, Jaksic T, et al.
J Pediatr Gastroenterol Nutr . 2013 Dec; 58(5):637-41. PMID: 24361903
Objective: The aim of the study was to determine, in a cohort of young children with intestinal failure (IF), whether the estimates of basal metabolic rate (BMR) by standard equations...