Yoko Fukuda-Yuzawa
Overview
Explore the profile of Yoko Fukuda-Yuzawa including associated specialties, affiliations and a list of published articles.
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18
Citations
950
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Recent Articles
1.
A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival
Abassah-Oppong S, Zoia M, Mannion B, Rouco R, Tissieres V, Spurrell C, et al.
Nat Commun
. 2024 Oct;
15(1):8793.
PMID: 39389973
Approximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However,...
2.
Rajderkar S, Paraiso K, Amaral M, Kosicki M, Cook L, Darbellay F, et al.
Nat Commun
. 2024 Mar;
15(1):2030.
PMID: 38448444
The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development....
3.
Rajderkar S, Paraiso K, Amaral M, Kosicki M, Cook L, Darbellay F, et al.
bioRxiv
. 2023 Jul;
PMID: 37425964
The genetic basis of craniofacial birth defects and general variation in human facial shape remains poorly understood. Distant-acting transcriptional enhancers are a major category of non-coding genome function and have...
4.
Rajderkar S, Barozzi I, Zhu Y, Hu R, Zhang Y, Li B, et al.
Commun Biol
. 2023 Apr;
6(1):435.
PMID: 37081156
Topologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotypes, but the...
5.
Spurrell C, Barozzi I, Kosicki M, Mannion B, Blow M, Fukuda-Yuzawa Y, et al.
Cell Rep
. 2022 Sep;
40(12):111400.
PMID: 36130500
Heart disease is associated with re-expression of key transcription factors normally active only during prenatal development of the heart. However, the impact of this reactivation on the regulatory landscape in...
6.
Gorkin D, Barozzi I, Zhao Y, Zhang Y, Huang H, Lee A, et al.
Nature
. 2021 Jan;
589(7842):E4.
PMID: 33398137
No abstract available.
7.
Gorkin D, Barozzi I, Zhao Y, Zhang Y, Huang H, Lee A, et al.
Nature
. 2020 Oct;
586(7831):E31.
PMID: 33037424
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Sethi A, Gu M, Gumusgoz E, Chan L, Yan K, Rozowsky J, et al.
Nat Methods
. 2020 Aug;
17(8):807-814.
PMID: 32737473
Enhancers are important non-coding elements, but they have traditionally been hard to characterize experimentally. The development of massively parallel assays allows the characterization of large numbers of enhancers for the...
9.
Gorkin D, Barozzi I, Zhao Y, Zhang Y, Huang H, Lee A, et al.
Nature
. 2020 Jul;
583(7818):744-751.
PMID: 32728240
The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental stages from 10.5 days after...
10.
Osterwalder M, Barozzi I, Tissieres V, Fukuda-Yuzawa Y, Mannion B, Afzal S, et al.
Nature
. 2018 Feb;
554(7691):239-243.
PMID: 29420474
Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber protein-coding genes in mammalian genomes, but the functional importance of this regulatory complexity remains unclear. Here we show that the pervasive...