Diane E Dickel
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Explore the profile of Diane E Dickel including associated specialties, affiliations and a list of published articles.
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63
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Recent Articles
1.
Moore J, Pratt H, Fan K, Phalke N, Fisher J, Elhajjajy S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763870
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated...
2.
Kim Y, Kim S, Saul D, Neyazi M, Schmid M, Wakimoto H, et al.
J Clin Invest
. 2024 Dec;
135(4).
PMID: 39688912
Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte (CM) TTN expression, we characterized...
3.
Yu M, Zemke N, Chen Z, Juric I, Hu R, Raviram R, et al.
Nat Struct Mol Biol
. 2024 Dec;
PMID: 39681766
While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on the basis of chromatin accessibility and histone modification patterns, delineating their role...
4.
Catta-Preta R, Lindtner S, Ypsilanti A, Seban N, Price J, Abnousi A, et al.
Dev Cell
. 2024 Oct;
60(2):288-304.e6.
PMID: 39481376
Transcription factors (TFs) bind combinatorially to cis-regulatory elements, orchestrating transcriptional programs. Although studies of chromatin state and chromosomal interactions have demonstrated dynamic neurodevelopmental cis-regulatory landscapes, parallel understanding of TF interactions...
5.
Kosicki M, Baltoumas F, Kelman G, Boverhof J, Ong Y, Cook L, et al.
Nucleic Acids Res
. 2024 Oct;
53(D1):D324-D330.
PMID: 39470740
Regulatory elements (enhancers) are major drivers of gene expression in mammals and harbor many genetic variants associated with human diseases. Here, we present an updated VISTA Enhancer Browser (https://enhancer.lbl.gov), a...
6.
A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival
Abassah-Oppong S, Zoia M, Mannion B, Rouco R, Tissieres V, Spurrell C, et al.
Nat Commun
. 2024 Oct;
15(1):8793.
PMID: 39389973
Approximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However,...
7.
Liu Z, Ypsilanti A, Markenscoff-Papadimitriou E, Dickel D, Sanders S, Dong S, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(40):e2402368121.
PMID: 39312666
There is evidence that transcription factor (TF) encoding genes, which temporally control development in multiple cell types, can have tens of enhancers that regulate their expression. The NR2F1 TF developmentally...
8.
Kosicki M, Zhang B, Pampari A, Akiyama J, Plajzer-Frick I, Novak C, et al.
bioRxiv
. 2024 Sep;
PMID: 39282388
Distant-acting enhancers are central to human development. However, our limited understanding of their functional sequence features prevents the interpretation of enhancer mutations in disease. Here, we determined the functional sensitivity...
9.
Bower G, Hollingsworth E, Jacinto S, Clock B, Cao K, Liu M, et al.
bioRxiv
. 2024 Jun;
PMID: 38826394
While most mammalian enhancers regulate their cognate promoters over moderate distances of tens of kilobases (kb), some enhancers act over distances in the megabase range. The sequence features enabling such...
10.
Chen Z, Snetkova V, Bower G, Jacinto S, Clock B, Dizehchi A, et al.
Nat Genet
. 2024 Mar;
56(4):675-685.
PMID: 38509385
Remote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here we investigate the three-dimensional (3D)...