Yogesh P Wairkar
Overview
Explore the profile of Yogesh P Wairkar including associated specialties, affiliations and a list of published articles.
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18
Citations
613
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Recent Articles
1.
Pradhan S, Bush K, Zhang N, Pandita R, Tsai C, Smith C, et al.
bioRxiv
. 2024 Sep;
PMID: 39345557
Highlights: BRG1 recruits HTT and NHEJ components to transcriptionally active DSBs.HTT joins BRG1 and PNKP to efficiently repair transcription related DSBs in brain.Mutant HTT impairs the functional integrity of TC-NHEJ...
2.
Pradhan S, Gao R, Bush K, Zhang N, Wairkar Y, Sarkar P
Front Cell Neurosci
. 2022 Apr;
16:837576.
PMID: 35444517
Emerging evidence suggests that DNA repair deficiency and genome instability may be the impending signs of many neurological diseases. Genome-wide association (GWAS) studies have established a strong correlation between genes...
3.
Bush K, Barber K, Martinez J, Tang S, Wairkar Y
Biol Open
. 2021 Jan;
10(1).
PMID: 33504470
The success of antiretroviral therapy (ART) has improved the survival of HIV-infected patients significantly. However, significant numbers of patients on ART whose HIV disease is well controlled show peripheral sensory...
4.
Barber K, Hruska M, Bush K, Martinez J, Fei H, Levitan I, et al.
Sci Rep
. 2018 Nov;
8(1):16099.
PMID: 30382129
Functional synaptic networks are compromised in many neurodevelopmental and neurodegenerative diseases. While the mechanisms of axonal transport and localization of synaptic vesicles and mitochondria are relatively well studied, little is...
5.
Barber K, Tanquary J, Bush K, Shaw A, Woodson M, Tangavelou K, et al.
PLoS Genet
. 2017 Jun;
13(5):e1006822.
PMID: 28562608
[This corrects the article DOI: 10.1371/journal.pgen.1006621.].
6.
Barber K, Tanquary J, Bush K, Shaw A, Woodson M, Sherman M, et al.
PLoS Genet
. 2017 Feb;
13(2):e1006621.
PMID: 28222093
Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role...
7.
Natarajan R, Barber K, Buckley A, Cho P, Egbejimi A, Wairkar Y
PLoS One
. 2015 Sep;
10(9):e0138188.
PMID: 26393506
Precise regulation of synapses during development is essential to ensure accurate neural connectivity and function of nervous system. Many signaling pathways, including the mTOR (mechanical Target of Rapamycin) pathway operate...
8.
Wairkar Y, Trivedi D, Natarajan R, Barnes K, Dolores L, Cho P
Dev Biol
. 2013 Oct;
384(1):53-64.
PMID: 24080510
Development and plasticity of synapses are brought about by a complex interplay between various signaling pathways. Typically, either changing the number of synapses or strengthening an existing synapse can lead...
9.
Natarajan R, Trivedi-Vyas D, Wairkar Y
Hum Mol Genet
. 2013 Feb;
22(10):2010-23.
PMID: 23393158
Mutations in the tuberous sclerosis complex (TSC) are associated with various forms of neurodevelopmental disorders, including autism and epilepsy. The heterodimeric TSC complex, consisting of Tsc1 and Tsc2 proteins, regulates...
10.
Lee A, Lamb R, Chang J, Erdmann-Gilmore P, Lichti C, Rohrs H, et al.
J Proteome Res
. 2012 Sep;
11(11):5515-26.
PMID: 22985349
Retinal ganglion cells (RGCs) transmit visual information topographically from the eye to the brain, creating a map of visual space in retino-recipient nuclei (retinotopy). This process is affected by retinal...