Yinshan Fang
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Explore the profile of Yinshan Fang including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
665
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Recent Articles
1.
Wei X, Qian W, Narasimhan H, Chan T, Liu X, Arish M, et al.
Science
. 2025 Mar;
387(6738):eadq2509.
PMID: 40048515
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory...
2.
Fang Y, Zhang S, Li X, Jiang F, Ye Q, Ning W
Sci Rep
. 2025 Feb;
15(1):4915.
PMID: 39929858
No abstract available.
3.
Fang Y, Chung S, Xu L, Xue C, Liu X, Jiang D, et al.
Nature
. 2025 Feb;
PMID: 39910313
A hallmark of pulmonary fibrosis is the aberrant activation of lung fibroblasts into pathological fibroblasts that produce excessive extracellular matrix. Thus, the identification of key regulators that promote the generation...
4.
Wang Z, Liu Z, Fang Y, Zhang H, Sun X, Hao N, et al.
Nat Commun
. 2025 Jan;
16(1):679.
PMID: 39814719
Accurately basecalling sequence backbones in the presence of nucleotide modifications remains a substantial challenge in nanopore sequencing bioinformatics. It has been extensively demonstrated that state-of-the-art basecallers are less compatible with...
5.
Fnu T, Shi P, Zhang W, Chung S, Damoci C, Fang Y, et al.
Cancer Discov
. 2024 Nov;
15(3):616-632.
PMID: 39513738
SCLC is highly aggressive, with limited effective treatment options. We show that ablating sympathetic nerves or inhibiting the ADRB2 receptor slows SCLC progression and prolongs survival in mice. Additionally, ADRB2...
6.
Zhang Y, Karagiannis D, Liu H, Lin M, Fang Y, Jiang M, et al.
Sci Adv
. 2024 Oct;
10(41):eadq0479.
PMID: 39383220
While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to...
7.
Wang Z, Tu M, Liu Z, Wang K, Fang Y, Hao N, et al.
bioRxiv
. 2024 Sep;
PMID: 39345479
Nucleotide modifications deviate nanopore sequencing readouts, therefore generating artifacts during the basecalling of sequence backbones. Here, we present an iterative approach to polish modification-disturbed basecalling results. We show such an...
8.
Wang Z, Liu Z, Fang Y, Zhang H, Sun X, Hao N, et al.
bioRxiv
. 2024 Sep;
PMID: 39257777
Accurately basecalling sequence backbones in the presence of nucleotide modifications remains a substantial challenge in nanopore sequencing bioinformatics. It has been extensively demonstrated that state-of-the-art basecallers are less compatible with...
9.
Wang Z, Fang Y, Liu Z, Hao N, Zhang H, Sun X, et al.
Nat Commun
. 2024 Aug;
15(1):7148.
PMID: 39169028
We leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the basecalling of modification-rich sequences, which...
10.
Fang Y, Zhang S, Li X, Jiang F, Ye Q, Ning W
Sci Rep
. 2024 Apr;
14(1):9592.
PMID: 38671029
No abstract available.