Yike Ni
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Explore the profile of Yike Ni including associated specialties, affiliations and a list of published articles.
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Citations
109
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Recent Articles
1.
Malamas M, Stange H, Schindler R, Lankau H, Grunwald C, Langen B, et al.
Bioorg Med Chem Lett
. 2012 Aug;
22(18):5876-84.
PMID: 22902656
The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported. The new analogs exhibit low-nanomolar potency for PDE10A, demonstrate high selectivity against all other...
2.
Malamas M, Ni Y, Erdei J, Stange H, Schindler R, Lankau H, et al.
J Med Chem
. 2011 Oct;
54(21):7621-38.
PMID: 21988093
The identification of highly potent and orally active phenylpyrazines for the inhibition of PDE10A is reported. The new analogues exhibit subnanomolar potency for PDE10A, demonstrate high selectivity against all other...
3.
Ni Y, Gopalsamy A, Cole D, Hu Y, Denny R, Ipek M, et al.
Bioorg Med Chem Lett
. 2011 Aug;
21(19):5952-6.
PMID: 21862328
We report here the synthesis and SAR of a new series of thieno[3,2-d]pyrimidines as potent Tpl2 kinase inhibitors. The proposed binding mode suggests the potential flipped binding mode depending on...
4.
Hu Y, Cole D, Aldrin Denny R, Anderson D, Ipek M, Ni Y, et al.
Bioorg Med Chem Lett
. 2011 Jul;
21(16):4758-61.
PMID: 21742493
Synthesis, modeling and structure-activity relationship of indazoles as inhibitors of Tpl2 kinase are described. From a high throughput screening effort, we identified an indazole hit compound 5 that has a...
5.
Ni Y, Kassab R, Chevliakov M, Montgomery J
J Am Chem Soc
. 2009 Nov;
131(48):17714-8.
PMID: 19899794
A unified approach to the pyrrolidine triacid natural products isodomoic acids G and H has been developed. Total syntheses of both natural products were completed, and determination of the correct...
6.
Ni Y, Montgomery J
J Am Chem Soc
. 2006 Feb;
128(8):2609-14.
PMID: 16492045
A new nickel-catalyzed procedure for the [4+2+1] cycloaddition of (trimethylsilyl)diazomethane with alkynes tethered to dienes has been developed. A broad range of unsaturated substrates participate in the sequence, and stereoselectivities...
7.
Storer R, Carrera D, Ni Y, MacMillan D
J Am Chem Soc
. 2006 Jan;
128(1):84-6.
PMID: 16390133
The first enantioselective organocatalytic reductive amination reaction has been accomplished. The development of a new chiral phosphoric acid catalyst has provided a convenient strategy for the enantioselective construction of protected...
8.
Ni Y, Montgomery J
J Am Chem Soc
. 2004 Sep;
126(36):11162-3.
PMID: 15355092
A new nickel-catalyzed procedure for the [4 + 2 + 1] cycloaddition of trimethylsilyl diazomethane with alkynes tethered to dienes has been developed. A broad range of unsaturated substrates participate...
9.
Ni Y, Amarasinghe K, Ksebati B, Montgomery J
Org Lett
. 2003 Sep;
5(20):3771-3.
PMID: 14507227
[structure: see text] The first total synthesis and stereochemical definition of isodomoic acid G has been achieved. The key nickel-catalyzed coupling of an alkynyl enone with an alkenylzirconium allows formation...
10.
Ni Y, Amarasinghe K, Montgomery J
Org Lett
. 2002 May;
4(10):1743-5.
PMID: 12000288
[reaction: see text] 1,3-Dienes were prepared by a variety of nickel-catalyzed couplings and cyclization processes. Intermolecular or partially intramolecular couplings of alkynes, vinylzirconium reagents, and either aldehydes or enones efficiently...