Yi Han Ng
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Explore the profile of Yi Han Ng including associated specialties, affiliations and a list of published articles.
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13
Citations
832
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Recent Articles
1.
Liu Z, Sun W, Ng Y, Dong H, Quake S, Sudhof T
Nature
. 2024 Jul;
632(8024):366-374.
PMID: 38961294
Social communication guides decision-making, which is essential for survival. Social transmission of food preference (STFP) is an ecologically relevant memory paradigm in which an animal learns a desirable food odour...
2.
Ng Y, Janas J
Methods Mol Biol
. 2023 Jun;
2683:39-51.
PMID: 37300765
The ability to differentiate pluripotent stem cells and to generate specific cell types is a long-standing goal of regenerative medicine. This can be accomplished by recreating the developmental trajectories using...
3.
Haddad Derafshi B, Danko T, Chanda S, Batista P, Litzenburger U, Lee Q, et al.
Sci Rep
. 2022 Dec;
12(1):22425.
PMID: 36575212
The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in the...
4.
Janas J, Zhang L, Luu J, Demeter J, Meng L, Marro S, et al.
Mol Cell
. 2022 Nov;
82(24):4627-4646.e14.
PMID: 36417913
Cell lineage specification is accomplished by a concerted action of chromatin remodeling and tissue-specific transcription factors. However, the mechanisms that induce and maintain appropriate lineage-specific gene expression remain elusive. Here,...
5.
Ng Y, Chanda S, Janas J, Yang N, Kokubu Y, Sudhof T, et al.
Stem Cell Reports
. 2021 Jun;
16(7):1763-1776.
PMID: 34171286
The differentiation of pluripotent stem cells can be accomplished by sequential activation of signaling pathways or through transcription factor programming. Multistep differentiation imitates embryonic development to obtain authentic cell types,...
6.
A Synaptic Circuit Required for Acquisition but Not Recall of Social Transmission of Food Preference
Wang C, Liu Z, Ng Y, Sudhof T
Neuron
. 2020 May;
107(1):144-157.e4.
PMID: 32369733
During social transmission of food preference (STFP), the combination of an olfactory sensory input with a social cue induces long-term memory of a food odor. How a social cue produces...
7.
Nobuta H, Yang N, Ng Y, Marro S, Sabeur K, Chavali M, et al.
Cell Stem Cell
. 2019 Oct;
25(4):531-541.e6.
PMID: 31585094
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major myelin protein, resulting in profound developmental delay and early lethality. Previous work...
8.
Zhou M, Liu Z, Melin M, Ng Y, Xu W, Sudhof T
Nat Neurosci
. 2018 Oct;
21(11):1515-1519.
PMID: 30349111
The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in...
9.
Lujan E, Zunder E, Ng Y, Goronzy I, Nolan G, Wernig M
Nature
. 2015 Apr;
521(7552):352-6.
PMID: 25830878
In the context of most induced pluripotent stem (iPS) cell reprogramming methods, heterogeneous populations of non-productive and staggered productive intermediates arise at different reprogramming time points. Despite recent reports claiming...
10.
Wapinski O, Vierbuchen T, Qu K, Lee Q, Chanda S, Fuentes D, et al.
Cell
. 2013 Nov;
155(3):621-35.
PMID: 24243019
Direct lineage reprogramming is a promising approach for human disease modeling and regenerative medicine, with poorly understood mechanisms. Here, we reveal a hierarchical mechanism in the direct conversion of fibroblasts...