Yen-Chang Clark Lai
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Explore the profile of Yen-Chang Clark Lai including associated specialties, affiliations and a list of published articles.
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83
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Recent Articles
1.
Chang S, Tu H, Lai Y, Luo C, Nejo T, Tanaka S, et al.
Diagnostics (Basel)
. 2020 May;
10(5).
PMID: 32349342
Glioma is characterized by a high heterogeneity in the brain tumor. Abundant tumor-associated macrophages (TAMs) exist as neoplastic tissues, implicating tumor plasticity and thus leading to therapeutic challenges. Vascular adhesion...
2.
Lai Y, Cheng C, Lee M, Chao W, Lai Y, Hsu Y, et al.
Int J Med Sci
. 2018 Dec;
15(14):1746-1756.
PMID: 30588199
We previously reported that modulation of cytokeratin18 induces pleomorphism of liver cells, higher cell motility, and higher drug sensitivity to sorafenib treatment of hepatoma cells. These relationships were established by...
3.
Lai Y, Chang S, Kostoro J, Kwan A, Chai C
APMIS
. 2018 Aug;
126(9):755-761.
PMID: 30160019
Recent studies suggest that vascular adhesion protein-1 (VAP-1), a 180-KDa homodimeric glycoprotein, may be associated with cancer-related events including tumor cell migration, motility, invasion, or metastasis. Therefore, this study applies...
4.
Lai Y, Cheng C, Lai Y, Liu Y
Cancer Genomics Proteomics
. 2017 Jun;
14(4):219-223.
PMID: 28647696
Unstable cytokeratins are associated with tumor transformation in the development of human hepatocellular carcinoma. We previously demonstrated that the cytokeratin 18 was modulated and that a histone H3-specific modification occured,...
5.
Cheng C, Chao W, Liao C, Tseng Y, Lai Y, Lai Y, et al.
Cell Adh Migr
. 2017 Mar;
12(1):19-27.
PMID: 28276928
Plectin involved in activation of kinases in cell signaling pathway and plays important role in cell morphology and migration. Plectin knockdown promotes cell migration by activating focal adhesion kinase and...
6.
Cheng C, Lai Y, Lai Y, Chao W, Tseng Y, Hsu Y, et al.
In Vivo
. 2016 Aug;
30(5):549-55.
PMID: 27566071
Background/aim: Nucleoskeleton maintains the framework of a cell nucleus that is required for a variety of nuclear functions. However, the nature of nucleoskeleton structure has not been yet clearly elucidated...
7.
Kostoro J, Chang S, Lai Y, Wu C, Chai C, Kwan A
APMIS
. 2016 Mar;
124(6):462-8.
PMID: 26935340
Vascular adhesion protein-1 (VAP-1) is one of the endothelial adhesion molecules that is believed to play a role in tumor progression and metastasis, supporting cancer cell extravasation. Very few studies...
8.
Cheng C, Liu Y, Lai Y, Hsu Y, Chao W, Lai Y
In Vivo
. 2015 Mar;
29(2):237-42.
PMID: 25792651
Background: Aberrant histone deacetylase expression may cause imbalance between acetylation and deacetylation of histone and play roles in tumor transformation. We found that histone 3 was modulated in human hepatocellular...
9.
Cheng C, Lai Y, Lai Y, Hsu Y, Chao W, Sia K, et al.
Cancer Cell Int
. 2015 Mar;
15:29.
PMID: 25774093
Background: Plectin is one of the cytolinker proteins that play a crucial role in maintaining the integrity of cellular architecture. It is a component of desmosome complexes connecting cytoskeletal proteins...
10.
Yoshizawa K, Kuro-Kuwata M, Sasaki T, Lai Y, Kanematsu S, Miki H, et al.
Toxicol Pathol
. 2011 Apr;
39(4):606-13.
PMID: 21498792
Seven-week-old female BALB/c mice received a single intraperitoneal injection of N-ethyl-N-nitrosourea (ENU) (50, 100, 200, 400, or 600 mg/kg), and retinal damage was evaluated after 7 days. Sequential morphological features...