Yasuhiro Onogi
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Explore the profile of Yasuhiro Onogi including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
258
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Recent Articles
11.
Ruiz-Ojeda F, Wang J, Backer T, Krueger M, Zamani S, Rosowski S, et al.
Mol Metab
. 2020 Dec;
45:101147.
PMID: 33359386
Objective: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation. However, very little is known...
12.
Watanabe E, Wada T, Okekawa A, Kitamura F, Komatsu G, Onogi Y, et al.
Angiogenesis
. 2020 Jul;
23(4):667-684.
PMID: 32699964
Platelet-derived growth factor-B (PDGF-B) is a main factor to promote adipose tissue angiogenesis, which is responsible for the tissue expansion in obesity. In this process, PDGF-B induces the dissociation of...
13.
Onogi Y, Khalil A, Ussar S
Biochem J
. 2020 Jul;
477(13):2509-2541.
PMID: 32648930
Adipose tissue is a central regulator of metabolism and an important pharmacological target to treat the metabolic consequences of obesity, such as insulin resistance and dyslipidemia. Among the various cellular...
14.
Ishikawa A, Wada T, Nishimura S, Ito T, Okekawa A, Onogi Y, et al.
PLoS One
. 2020 Apr;
15(4):e0230885.
PMID: 32240221
Regulatory T cells (Treg) play essential roles in maintaining immune homeostasis. Resident Treg in visceral adipose tissue (VAT-Treg) decrease in male obese mice, which leads to the development of obesity-associated...
15.
Nishida Y, Nawaz A, Kado T, Takikawa A, Igarashi Y, Onogi Y, et al.
J Cachexia Sarcopenia Muscle
. 2020 Feb;
11(1):241-258.
PMID: 32003547
Background: Skeletal muscle is mainly responsible for insulin-stimulated glucose disposal. Dysfunction in skeletal muscle metabolism especially during obesity contributes to the insulin resistance. Astaxanthin (AX), a natural antioxidant, has been...
16.
Onogi Y, Wada T, Okekawa A, Matsuzawa T, Watanabe E, Ikeda K, et al.
Sci Rep
. 2020 Jan;
10(1):670.
PMID: 31959796
Adipose tissue macrophages (ATMs) play a central role in tissue remodeling and homeostasis. However, whether ATMs promote adipose angiogenesis in obesity remains unclear. We examined the impact of ATMs deletion...
17.
Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, et al.
J Endocrinol
. 2017 Sep;
235(3):179-191.
PMID: 28855315
Obesity-associated activation of the renin-angiotensin-aldosterone system is implicated in the pathogenesis of insulin resistance; however, influences of mineralocorticoid receptor (MR) inhibition remain unclear. Therefore, we aimed to clarify the anti-inflammatory...
18.
Onogi Y, Wada T, Kamiya C, Inata K, Matsuzawa T, Inaba Y, et al.
Diabetes
. 2017 Jan;
66(4):1008-1021.
PMID: 28122789
Platelet-derived growth factor (PDGF) is a key factor in angiogenesis; however, its role in adult obesity remains unclear. In order to clarify its pathophysiological role, we investigated the significance of...
19.
Wada T, Onogi Y, Kimura Y, Nakano T, Fusanobori H, Ishii Y, et al.
Eur J Pharmacol
. 2013 Mar;
707(1-3):120-9.
PMID: 23528355
Cilostazol, an inhibitor of phosphodiesterase 3B, is widely used as an anti-platelet drug in diabetic patients. Recently, cilostazol has been shown to promote preadipocyte differentiation to mature adipocyte and affect...