Yasuhiro Arimura
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Explore the profile of Yasuhiro Arimura including associated specialties, affiliations and a list of published articles.
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43
Citations
848
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Recent Articles
1.
Barrero D, Wijeratne S, Zhao X, Cunningham G, Yan R, Nelson C, et al.
Curr Biol
. 2024 Aug;
34(17):3881-3893.e5.
PMID: 39127048
Eukaryotic chromosome segregation requires kinetochores, multi-megadalton protein machines that assemble on the centromeres of chromosomes and mediate attachments to dynamic spindle microtubules. Kinetochores are built from numerous complexes, and there...
2.
Arimura Y, Konishi H, Funabiki H
bioRxiv
. 2024 Feb;
PMID: 38328033
Cryo-EM single-particle analyses typically require target macromolecule concentration at 0.05~5.0 mg/ml, which is often difficult to achieve. Here, we devise Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct structural...
3.
Ohnuki J, Arimura Y, Kono T, Kino K, Kurumizaka H, Takano M
J Am Chem Soc
. 2023 Jul;
145(29):15963-15970.
PMID: 37452763
A nonribosomal peptide-synthesizing molecular machine, RimK, adds l-glutamic acids to the C-terminus of ribosomal protein S6 (RpsF) in vivo and synthesizes poly-α-glutamates in vitro. However, the mechanism of the successive...
4.
Furukawa A, Wakamori M, Arimura Y, Ohtomo H, Tsunaka Y, Kurumizaka H, et al.
iScience
. 2022 Nov;
25(11):105408.
PMID: 36325057
[This corrects the article DOI: 10.1016/j.isci.2022.103937.].
5.
Furukawa A, Wakamori M, Arimura Y, Ohtomo H, Tsunaka Y, Kurumizaka H, et al.
iScience
. 2022 Mar;
25(3):103937.
PMID: 35265811
The nucleosome core particle (NCP) comprises a histone octamer, wrapped around by ∼146-bp DNA, while the nucleosome additionally contains linker DNA. We previously showed that, in the nucleosome, H4 N-tail...
6.
Arimura Y, Funabiki H
J Mol Biol
. 2021 Dec;
434(5):167413.
PMID: 34942166
Alpha-2-Macroglobulin (A2M) is the critical pan-protease inhibitor of the innate immune system. When proteases cleave the A2M bait region, global structural transformation of the A2M tetramer is triggered to entrap...
7.
Arimura Y, Shih R, Froom R, Funabiki H
Mol Cell
. 2021 Sep;
81(21):4377-4397.e12.
PMID: 34478647
Structural heterogeneity of nucleosomes in functional chromosomes is unknown. Here, we devise the template-, reference- and selection-free (TRSF) cryo-EM pipeline to simultaneously reconstruct cryo-EM structures of protein complexes from interphase...
8.
Ohtomo H, Kurita J, Sakuraba S, Li Z, Arimura Y, Wakamori M, et al.
J Mol Biol
. 2021 Jun;
433(15):167110.
PMID: 34153285
The nucleosome comprises two histone dimers of H2A-H2B and one histone tetramer of (H3-H4), wrapped around by ~145 bp of DNA. Detailed core structures of nucleosomes have been established by...
9.
Hirano R, Arimura Y, Kujirai T, Shibata M, Okuda A, Morishima K, et al.
Commun Biol
. 2021 Feb;
4(1):191.
PMID: 33580188
H2A.B is an evolutionarily distant histone H2A variant that accumulates on DNA repair sites, DNA replication sites, and actively transcribing regions in genomes. In cells, H2A.B exchanges rapidly in chromatin,...
10.
Ho C, Takizawa Y, Kobayashi W, Arimura Y, Kimura H, Kurumizaka H
Life Sci Alliance
. 2021 Feb;
4(4).
PMID: 33574035
SET8 is solely responsible for histone H4 lysine-20 (H4K20) monomethylation, which preferentially occurs in nucleosomal H4. However, the underlying mechanism by which SET8 specifically promotes the H4K20 monomethylation in the...