Yasuhiko Okimura
Overview
Explore the profile of Yasuhiko Okimura including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
753
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Recent Articles
1.
Sawa R, Ohnishi A, Ohno M, Nagata M, Wake I, Okimura Y
Biochim Biophys Acta Gen Subj
. 2022 May;
1866(9):130174.
PMID: 35597502
Background: Sestrin2 is a conserved protein in several species, and its expression is upregulated in cells under various environmental stresses. Sestrin2 content is involved in the function of mechanistic target...
2.
Sawa R, Wake I, Yamamoto Y, Okimura Y
Growth Horm IGF Res
. 2021 Jun;
59:101406.
PMID: 34126555
Objective: IGF-I and branched-chain amino acids have been reported to promote muscle hypertrophy via the stimulation of protein synthesis. Sestrin2, the function of which is regulated by leucine, has been...
3.
Kanie K, Bando H, Iguchi G, Muguruma K, Matsumoto R, Hidaka-Takeno R, et al.
J Endocr Soc
. 2019 Oct;
3(11):1969-1978.
PMID: 31620667
Context: Anti-pituitary-specific transcriptional factor-1 (anti-PIT-1) antibody syndrome is characterized by acquired and specific deficiencies in growth hormone, prolactin, and thyroid-stimulating hormone. Although PIT-1-reactive cytotoxic T lymphocytes (CTLs) have been speculated...
4.
Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, et al.
Growth Horm IGF Res
. 2018 Oct;
42-43:66-73.
PMID: 30273774
Objective: Branched-chain amino acids (BCAAs) have been reported to inhibit several types of muscle atrophy via the activation of the mechanistic target of rapamycin complex 1 (mTORC1). However, we previously...
5.
Yamamoto Y, Sawa R, Wake I, Morimoto A, Okimura Y
Nutr Res
. 2017 Dec;
47:13-20.
PMID: 29241574
Branched chain amino acids (BCAAs) have protective effects against muscle atrophy. Although plasma BCAA concentrations are higher in patients with diabetes than in healthy subjects, diabetes is related to sarcopenia....
6.
Bando H, Iguchi G, Okimura Y, Odake Y, Yoshida K, Matsumoto R, et al.
Sci Rep
. 2017 Feb;
7:43060.
PMID: 28216655
Anti-PIT-1 antibody syndrome has recently been reported and characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with autoimmunity to a pituitary specific transcription factor...
7.
Nishida H, Ikegami A, Kaneko C, Kakuma H, Nishi H, Tanaka N, et al.
PLoS One
. 2015 Jun;
10(6):e0128805.
PMID: 26086773
Branched-chain amino acids (BCAAs) and IGF-I, the secretion of which is stimulated by growth hormone (GH), prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA...
8.
Bando H, Iguchi G, Fukuoka H, Yamamoto M, Hidaka-Takeno R, Okimura Y, et al.
J Clin Endocrinol Metab
. 2014 Jun;
99(9):E1744-9.
PMID: 24937538
Context: Anti-pituitary-specific transcriptional factor 1 (PIT-1) antibody syndrome is characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with circulating anti-PIT-1 antibodies. Although autoimmunity to...
9.
Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, et al.
Mol Cell Endocrinol
. 2013 Jun;
376(1-2):93-8.
PMID: 23732115
PROP1 mutation causes combined pituitary hormone deficiency (CPHD). Several mutations are located in a transactivation domain (TAD) of Prop1, and the loss of TAD binding to cofactors is likely the...
10.
Okada M, Matsuda H, Okimura Y
PLoS One
. 2013 Jan;
8(1):e54437.
PMID: 23342159
Previous studies have shown that the locus control region (LCR) and the promoter of the growth hormone (GH) gene can control the expression of GH. Therefore, lenti- and retro-viral vectors...