Yasuaki Hashimoto
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Explore the profile of Yasuaki Hashimoto including associated specialties, affiliations and a list of published articles.
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13
Citations
141
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Recent Articles
1.
Yamada H, Mori H, Nakanishi Y, Nishikawa S, Hashimoto Y, Ochi Y, et al.
Int J Rheumatol
. 2019 Mar;
2019:5710340.
PMID: 30906325
We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA...
2.
Yamada H, Ochi Y, Mori H, Nishikawa S, Hashimoto Y, Tanaka M, et al.
J Bone Miner Metab
. 2018 Oct;
37(4):636-647.
PMID: 30357565
This study evaluated the long-term effects of the cathepsin K inhibitor ONO-5334 on bone mass and strength in ovariectomised (OVX) cynomolgus monkeys. Animals were assigned to one of the following...
3.
Yamada H, Ochi Y, Mori H, Nishikawa S, Hashimoto Y, Nakanishi Y, et al.
Bone
. 2016 Feb;
86:43-52.
PMID: 26921823
We examined the effects of ONO-5334, a cathepsin K inhibitor, on bone markers, BMD, strength and histomorphometry in ovariectomized (OVX) cynomolgus monkeys. ONO-5334 (1.2, 6 and 30mg/kg/day, p.o.), alendronate (0.05mg/kg/2weeks,...
4.
Ochi Y, Yamada H, Mori H, Nakanishi Y, Nishikawa S, Kayasuga R, et al.
Bone
. 2014 May;
65:1-8.
PMID: 24784023
This study examined the effect of ONO-5334, a cathepsin K inhibitor, on bone turnover, mineral density (BMD), mechanical strength and microstructure in ovariectomized (OVX) cynomolgus monkeys. Vehicle, ONO-5334 (3, 10...
5.
Ochi Y, Yamada H, Mori H, Nakanishi Y, Nishikawa S, Kayasuga R, et al.
Bone
. 2011 Oct;
49(6):1351-6.
PMID: 21982869
In the present study, we examined the in vitro and in vivo pharmacological effects of ONO-5334, a novel inhibitor of cathepsin K, on bone metabolism. In vitro experiments indicated that...
6.
Hashimoto Y, Shuto T, Mizunoe S, Tomita A, Koga T, Sato T, et al.
Lab Invest
. 2010 Dec;
91(4):509-18.
PMID: 21135815
Pruritus, also known as itch, is a sensation that causes a desire to scratch. Prolonged scratching exacerbates skin lesions in several skin diseases such as atopic dermatitis. Here, we identify...
7.
Hashimoto Y, Okiyoneda T, Harada K, Ueno K, Sugahara T, Yamashita A, et al.
Biochim Biophys Acta
. 2007 Oct;
1783(1):153-62.
PMID: 17936375
The cystic fibrosis transmembrane conductance regulator (CFTR) is transported to the plasma membrane from endoplasmic reticulum (ER) through the Golgi. Crucial to these trafficking events is the role of not...
8.
Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin
Harada K, Okiyoneda T, Hashimoto Y, Oyokawa K, Nakamura K, Suico M, et al.
Biochem Biophys Res Commun
. 2006 Dec;
353(2):351-6.
PMID: 17178109
Curcumin has been reported to correct cystic fibrosis caused by the DeltaF508 mutation of the cystic fibrosis transmembrane regulator (CFTR) but its mechanistic action remains unclear. We have recently demonstrated...
9.
Okiyoneda T, Niibori A, Harada K, Kohno T, Hashimoto Y, Kusuhara H, et al.
Biochim Biophys Acta
. 2006 Sep;
1763(10):1017-23.
PMID: 17005267
Cystic fibrosis (CF) is the most common lethal genetic disease in Caucasians caused by the trafficking defects of CF transmembrane conductance regulator (CFTR), which is a cAMP-dependent Cl- channel at...
10.
Iwakawa S, Miyashita K, Hashimoto Y, Kuroda T
Biol Pharm Bull
. 2006 Sep;
29(9):1983-5.
PMID: 16946524
The effect of glimepiride on metabolism of S-warfarin to 7-hydroxywarfarin was studied using human liver microsomes and recombinant cytochrome P450 2C9 microsomes (CYP2C9.1 and CYP2C9.3), and was compared with the...