Yash R Somnay
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Explore the profile of Yash R Somnay including associated specialties, affiliations and a list of published articles.
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10
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99
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Recent Articles
1.
Somnay Y, Wang A, Griffiths K, Levy R
Mitochondrion
. 2022 May;
65:1-10.
PMID: 35500860
Brown adipose tissue (BAT) mitochondria generate heat via uncoupled respiration due to excessive proton leak through uncoupling proteins (UCPs). We previously found hyperthermia in a newborn mouse model of fragile ...
2.
Somnay Y, Schneider D, Mazeh H
Atlas Genet Cytogenet Oncol Haematol
. 2017 Jan;
17(4):291-296.
PMID: 28111594
Medullary thyroid cancers (MTC) are rare neuroendocrine tumors arising from the parafollicular C-cells of the thyroid. In this review, we provide a general overview of the classification, pathology, and clinical...
3.
Somnay Y, Kunnimalaiyaan M
Glob J Biochem
. 2016 Dec;
3.
PMID: 27990410
The phosphatidylinositol 3-kinase (PI3K)-Akt pathway is often aberrantly activated in neuroendocrine-derived cancers. Therefore, selectively targeting this pathway using small-molecule inhibitors may reduce neuroendocrine tumor burden, potentiate adjunct therapies, and achieve...
4.
Somnay Y, Craven M, McCoy K, Carty S, Wang T, Greenberg C, et al.
Surgery
. 2016 Dec;
161(4):1113-1121.
PMID: 27989606
Background: Parathyroidectomy offers the only cure for primary hyperparathyroidism, but today only 50% of primary hyperparathyroidism patients are referred for operation, in large part, because the condition is widely under-recognized....
5.
Somnay Y, Yu X, Lloyd R, Leverson G, Aburjania Z, Jang S, et al.
Cancer
. 2016 Nov;
123(5):769-782.
PMID: 27861750
Background: Thyroid tumorigenesis is characterized by a progressive loss of differentiation exhibited by a range of disease variants. The Notch receptor family (1-4) regulates developmental progression in both normal and...
6.
Yu X, Jaskula-Sztul R, Georgen M, Aburjania Z, Somnay Y, Leverson G, et al.
Clin Cancer Res
. 2016 Feb;
22(14):3582-92.
PMID: 26847059
Purpose: Notch1, a transmembrane receptor, has been recently shown to aid in the determination of thyroid cell fate associated with tumorigenesis. This study aimed to investigate the clinical relevance of...
7.
Somnay Y, Weinlander E, Alfhefdi A, Schneider D, Sippel R, Chen H
J Surg Res
. 2015 Mar;
195(2):406-11.
PMID: 25770735
Background: Tertiary hyperparathyroidism (3HPT) is defined as the persistent hyperproduction of parathyroid hormone and resulting hypercalcemia after renal transplantation. Here, we examine the utility of radioguided parathyroidectomy (RGP) in patients...
8.
Somnay Y, Weinlander E, Schneider D, Sippel R, Chen H
Surgery
. 2014 Dec;
156(6):1308-13.
PMID: 25456900
Introduction: Tertiary hyperparathyroidism (3HPTH) patients who undergo parathyroidectomy (PTX) are often managed with calcium lowering medications such as cinacalcet (Sensipar) before surgery. Here, we assess how cinacalcet treatment influences intraoperative...
9.
Murphy J, Spalding A, Somnay Y, Markwart S, Ray M, Hamstra D
Clin Cancer Res
. 2009 Jan;
15(2):589-96.
PMID: 19147764
Purpose: The PI3K/Akt/mTOR prosurvival pathway is frequently up-regulated in soft tissue sarcoma. Mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin, have recently shown clinical benefit in soft tissue sarcoma,...
10.
Murphy J, Lucas D, Somnay Y, Hamstra D, Ray M
Transl Oncol
. 2008 Jul;
1(1):50-6.
PMID: 18607508
Background/purpose: Local and systemic control of soft tissue sarcoma (STS) remains a clinical challenge, particularly for retroperitoneal, deep truncal, or advanced extremity disease. 2',2'-Difluoro-2'-deoxycytidine (gemcitabine) is a potent radiosensitizer in...