Yannick D Benoit
Overview
Explore the profile of Yannick D Benoit including associated specialties, affiliations and a list of published articles.
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40
Citations
1014
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Recent Articles
1.
Bergin C, Zouggar A, Mendes da Silva A, Fenouil T, Haebe J, Masibag A, et al.
Nat Cancer
. 2024 Feb;
5(3):463-480.
PMID: 38351181
Cancer stem cells (CSCs), functionally characterized by self-renewal and tumor-initiating activity, contribute to decreased tumor immunogenicity, while fostering tumor growth and metastasis. Targeting G9a histone methyltransferase (HMTase) effectively blocks CSC...
2.
Billingsley J, Yevdokimova V, Ayoub K, Benoit Y
Cancers (Basel)
. 2023 Oct;
15(20).
PMID: 37894295
Colorectal tumors are heterogenous cellular systems harboring small populations of self-renewing and highly tumorigenic cancer stem cells (CSCs). Understanding the mechanisms fundamental to the emergence of CSCs and colorectal tumor...
3.
Mendes da Silva A, Yevdokimova V, Benoit Y
Cancer Metastasis Rev
. 2023 Oct;
43(1):441-456.
PMID: 37792222
Sam68 (Src associated in mitosis of 68 kDa) is an RNA-binding and multifunctional protein extensively characterized in numerous cellular functions, such as RNA processing, cell cycle regulation, kinase- and growth...
4.
Bergin C, Mendes da Silva A, Benoit Y
Cancers (Basel)
. 2023 Aug;
15(16).
PMID: 37627147
The frequency of somatic retrotranspositions of Long Interspersed Nuclear Elements 1 (LINE1) over a lifetime in healthy colonic epithelium and colorectal tumors has recently been reported. Indicative of a cell...
5.
Orlando L, Benoit Y, Reid J, Nakanishi M, Boyd A, Garcia-Rodriguez J, et al.
Cell Chem Biol
. 2023 Jun;
30(7):780-794.e8.
PMID: 37379846
Overlapping principles of embryonic and tumor biology have been described, with recent multi-omics campaigns uncovering shared molecular profiles between human pluripotent stem cells (hPSCs) and adult tumors. Here, using a...
6.
Bergin C, Benoit Y
STAR Protoc
. 2022 Mar;
3(1):101218.
PMID: 35265864
Organoids can enable the study of solid tumors initiated from a single cancer stem cell (CSC) vivo. We describe a serial tumor organoid plating protocol using primary colorectal cancer (CRC)...
7.
Masibag A, Bergin C, Haebe J, Zouggar A, Shah M, Sandouka T, et al.
iScience
. 2021 Dec;
24(12):103442.
PMID: 34877499
Cancer stem cells (CSCs) are documented to play a key role in tumorigenesis and therapy resistance. Despite significant progress in clinical oncology, CSC reservoirs remain elusive and difficult to eliminate....
8.
Haebe J, Bergin C, Sandouka T, Benoit Y
Oncogenesis
. 2021 Nov;
10(11):76.
PMID: 34775469
The histone methyltransferase G9a is well-documented for its implication in neoplastic growth. However, recent investigations have demonstrated a key involvement of this chromatin writer in maintaining the self-renewal and tumor-initiating...
9.
Benoit Y, Mitchell R, Wang W, Orlando L, Boyd A, Tanasijevic B, et al.
Cell Chem Biol
. 2021 May;
28(10):1394-1406.e10.
PMID: 33979648
Natural products (NPs) encompass a rich source of bioactive chemical entities. Here, we used human cancer stem cells (CSCs) in a chemical genomics campaign with NP chemical space to interrogate...
10.
Aslostovar L, Boyd A, Benoit Y, Lu J, Garcia Rodriguez J, Nakanishi M, et al.
Cell Rep Med
. 2021 Mar;
2(2):100202.
PMID: 33665638
The aberrant expression of dopamine receptors (DRDs) in acute myeloid leukemia (AML) cells has encouraged the repurposing of DRD antagonists such as thioridazine (TDZ) as anti-leukemic agents. Here, we access...