Yang W Zhang
Overview
Explore the profile of Yang W Zhang including associated specialties, affiliations and a list of published articles.
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12
Citations
826
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Recent Articles
1.
Zhang Y, Gallagher K, Angelis D, Rominger D, Scherle P, Vaddi K
Curr Protoc
. 2021 Feb;
1(2):e51.
PMID: 33587334
Evaluation of in vivo potencies plays an important role in drug discovery. Traditionally, the cellular activity and percent of plasma protein binding of a test agent are evaluated separately, with...
2.
Snyder K, Zitzer N, Gao Y, Choe H, Sell N, Neidemire-Colley L, et al.
JCI Insight
. 2020 Mar;
5(8).
PMID: 32191634
Acute graft-versus-host disease (aGVHD) is a T cell-mediated immunological disorder and the leading cause of nonrelapse mortality in patients who receive allogeneic hematopoietic cell transplants. Based on recent observations that...
3.
Lin H, Wang M, Zhang Y, Tong S, Leal R, Shetty R, et al.
ACS Med Chem Lett
. 2019 Jul;
10(7):1033-1038.
PMID: 31312404
Protein arginine methyltransferase 5 (PRMT5) is known to symmetrically dimethylate numerous cytosolic and nuclear proteins that are involved in a variety of cellular processes. Recent findings have revealed its potential...
4.
Xie W, Kagiampakis I, Pan L, Zhang Y, Murphy L, Tao Y, et al.
Cancer Cell
. 2018 Feb;
33(2):309-321.e5.
PMID: 29438699
Overall shared DNA methylation patterns between senescence (Sen) and cancers have led to the model that tumor-promoting epigenetic patterns arise through senescence. We show that transformation-associated methylation changes arise stochastically...
5.
Ye F, Kong X, Zhang H, Liu Y, Shao Z, Jin J, et al.
ACS Chem Biol
. 2018 Jan;
13(3):772-781.
PMID: 29381856
DNA methyltransferase-1 (DNMT1) plays a crucial role in the maintenance of genomic methylation patterns. The crystal structure of DNMT1 was determined in two different states in which the helix that...
6.
Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al.
Cancer Cell
. 2017 May;
31(5):653-668.e7.
PMID: 28486105
An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites...
7.
Cai Y, Tsai H, Yen R, Zhang Y, Kong X, Wang W, et al.
Genome Res
. 2017 Feb;
27(4):533-544.
PMID: 28232479
Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm. Maximizing this potential requires defining precisely how these enzymes maintain...
8.
Zhang Y, Wang Z, Xie W, Cai Y, Xia L, Easwaran H, et al.
Mol Cell
. 2017 Jan;
65(2):323-335.
PMID: 28107650
TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define...
9.
Zimmerlin L, Park T, Huo J, Verma K, Pather S, Talbot Jr C, et al.
Development
. 2016 Sep;
143(23):4368-4380.
PMID: 27660325
The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve...
10.
Liu M, Ohtani H, Zhou W, Orskov A, Charlet J, Zhang Y, et al.
Proc Natl Acad Sci U S A
. 2016 Aug;
113(37):10238-44.
PMID: 27573823
Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis)...