Yana van der Weegen
Overview
Explore the profile of Yana van der Weegen including associated specialties, affiliations and a list of published articles.
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10
Citations
252
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Recent Articles
1.
Kokic G, Yakoub G, van den Heuvel D, Wondergem A, van der Meer P, van der Weegen Y, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(3):536-547.
PMID: 38316879
During transcription-coupled DNA repair (TCR), RNA polymerase II (Pol II) transitions from a transcriptionally active state to an arrested state that allows for removal of DNA lesions. This transition requires...
2.
van der Weegen Y, de Lint K, van den Heuvel D, Nakazawa Y, Mevissen T, van Schie J, et al.
Nat Cell Biol
. 2021 Jun;
23(6):595-607.
PMID: 34108663
Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA damage-induced binding of the TCR-specific repair factor CSB to RNA polymerase II (RNAPII) triggers RNAPII ubiquitylation of a single...
3.
van den Heuvel D, van der Weegen Y, Boer D, Ogi T, Luijsterburg M
Trends Cell Biol
. 2021 Mar;
31(5):359-371.
PMID: 33685798
DNA lesions pose a major obstacle during gene transcription by RNA polymerase II (RNAPII) enzymes. The transcription-coupled DNA repair (TCR) pathway eliminates such DNA lesions. Inherited defects in TCR cause...
4.
van den Heuvel D, Spruijt C, Gonzalez-Prieto R, Kragten A, Paulsen M, Zhou D, et al.
Nat Commun
. 2021 Feb;
12(1):1342.
PMID: 33637760
Bulky DNA lesions in transcribed strands block RNA polymerase II (RNAPII) elongation and induce a genome-wide transcriptional arrest. The transcription-coupled repair (TCR) pathway efficiently removes transcription-blocking DNA lesions, but how...
5.
Avagliano Trezza R, Punt A, Mientjes E, van den Berg M, Zampeta F, de Graaf I, et al.
Sci Rep
. 2021 Feb;
11(1):3007.
PMID: 33542309
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by brain-specific loss of UBE3A, an E3 ubiquitin protein ligase. A substantial number of possible ubiquitination targets of UBE3A have been...
6.
van der Weegen Y, Golan-Berman H, Mevissen T, Apelt K, Gonzalez-Prieto R, Goedhart J, et al.
Nat Commun
. 2020 Nov;
11(1):5734.
PMID: 33159085
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
van der Weegen Y, Golan-Berman H, Mevissen T, Apelt K, Gonzalez-Prieto R, Goedhart J, et al.
Nat Commun
. 2020 May;
11(1):2104.
PMID: 32355176
The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. The function of the TCR proteins CSB, CSA...
8.
Liebelt F, Schimmel J, Verlaan-de Vries M, Klemann E, van Royen M, van der Weegen Y, et al.
Nucleic Acids Res
. 2019 Nov;
48(1):231-248.
PMID: 31722399
Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive disease, caused by inherited defects in the CSA and CSB genes, leading to defects in transcription-coupled nucleotide excision repair...
9.
Pines A, Dijk M, Makowski M, Meulenbroek E, Vrouwe M, van der Weegen Y, et al.
Nat Commun
. 2018 Mar;
9(1):1040.
PMID: 29531219
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to...
10.
Wadman R, Stam M, Jansen M, van der Weegen Y, Wijngaarde C, Harschnitz O, et al.
PLoS One
. 2016 Nov;
11(11):e0167087.
PMID: 27893852
Background: Clinical trials to test safety and efficacy of drugs for patients with spinal muscular atrophy (SMA) are currently underway. Biomarkers that document treatment-induced effects are needed because disease progression...