Y Yamazoe
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Explore the profile of Y Yamazoe including associated specialties, affiliations and a list of published articles.
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200
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1147
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Recent Articles
1.
Li Z, Okano S, Yoshinari K, Miyamoto T, Yamazoe Y, Shinya K, et al.
Lab Anim
. 2009 Jan;
43(2):205-11.
PMID: 19116287
Red cedar-derived bedding materials cause changes in cytochrome P450-dependent microsomal enzyme systems in laboratory animals. We examined the effect of essential oil of red cedar (EORC), as well as the...
2.
Shimada M, Matsuda T, Sato A, Akase T, Matsubara T, Nagata K, et al.
Xenobiotica
. 2008 Nov;
38(12):1487-99.
PMID: 18979284
1. St2b2, a mouse cytosolic sulfotransferase, predominantly catalyses epidermal cholesterol sulfation. St2b2 was found in the basement layer by immunohistochemical analysis of normal mouse skin. The highest expression level was...
3.
Miyata M, Watase H, Hori W, Shimada M, Nagata K, Gonzalez F, et al.
Xenobiotica
. 2006 Jul;
36(7):631-44.
PMID: 16864508
The efficient clearance of toxic bile acids such as lithocholic acid (LCA) requires drug-metabolizing enzymes. We therefore assessed the influence of pregnenolone 16alpha-carbonitrile (PCN) treatment on LCA-induced hepatotoxicity and disposition...
4.
Yamamoto T, Itoga H, Kohno Y, Nagata K, Yamazoe Y
Xenobiotica
. 2005 Sep;
35(6):627-46.
PMID: 16192112
Intrinsic clearances (CLint-HLM-total) for the metabolism of NE-100, metoprolol, clarithromycin (CAM), lornoxicam and tenoxicam were predicted from in vitro data with recombinant cytochorme P450s (CYPs) using relative activity factor (RAF)...
5.
Yamamoto T, Hagima N, Nakamura M, Kohno Y, Nagata K, Yamazoe Y
Xenobiotica
. 2005 Jan;
34(7):687-703.
PMID: 15672756
1. It has previously been reported that N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) was predominantly metabolized by cytochrome P450 (CYP) 2D6 in human liver microsomes (HLM). In the present study, the contribution of...
6.
Matsubara T, Kim H, Miyata M, Shimada M, Nagata K, Yamazoe Y
J Pharmacol Exp Ther
. 2004 Mar;
309(3):1282-90.
PMID: 15004215
Based on information of the nucleotide sequence obtained from rat genome clones, a new CYP3A (CYP3A62) cDNA was isolated from the cDNA library of a rat liver. The CYP3A62 cDNA...
7.
Matsumoto S, Hirama T, Kim H, Nagata K, Yamazoe Y
Xenobiotica
. 2003 Jul;
33(6):615-23.
PMID: 12851038
1. The effects of chemical agents on the metabolism of the antihistamine drug astemizole were investigated to evaluate drug-drug interactions. 2. Chemical inhibitors of astemizole O-demethylation were screened using the...
8.
Shimada M, Yoshinari K, Tanabe E, Shimakawa E, Kobashi M, Nagata K, et al.
Brain Res
. 2001 Nov;
920(1-2):222-5.
PMID: 11716829
A hydroxysteroid sulfotransferase (ST2A1) was identified as a form mediating neurosteroid sulfation in rat brain. The sole expression among known rat ST2A forms was indicated by brain RT-PCR. All nucleotide...
9.
Yamazoe Y, Nagata K
Nihon Rinsho
. 2001 Aug;
59(8):1614-23.
PMID: 11519169
Genetic polymorphisms of drug metabolizing enzymes often associated with clinical alteration among individuals. Current understanding of the molecular basis of the polymorphism of drug metabolizing enzymes is reviewed, particularly on...
10.
Miyata M, Furukawa M, Takahashi K, Gonzalez F, Yamazoe Y
Jpn J Pharmacol
. 2001 Aug;
86(3):302-9.
PMID: 11488430
The polycyclic aromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (DMBA), is an immunosuppressor as well as a potent organ-specific carcinogen. To understand the organ-specific mechanism of DMBA-induced lymphoid toxicity, aryl hydrocarbon-nonresponsive mice and microsomal...