Y Vijayendar Reddy
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Explore the profile of Y Vijayendar Reddy including associated specialties, affiliations and a list of published articles.
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11
Citations
39
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Recent Articles
1.
Wang Y, Reddy Y, Al Temimi A, Venselaar H, Nelissen F, Lenstra D, et al.
Biochem J
. 2019 Mar;
476(7):1109-1119.
PMID: 30898847
The biologically important carnitine biosynthesis pathway in humans proceeds via four enzymatic steps. The first step in carnitine biosynthesis is catalyzed by trimethyllysine hydroxylase (TMLH), a non-heme Fe(II) and 2-oxoglutarate...
2.
Al Temimi A, Reddy Y, White P, Guo H, Qian P, Mecinovic J
Sci Rep
. 2017 Nov;
7(1):16148.
PMID: 29170487
Histone lysine methyltransferases (KMTs) represent an important class of epigenetic enzymes that play essential roles in regulation of gene expression in humans. Members of the KMT family catalyze the transfer...
3.
Reddy Y, Al Temimi A, Mecinovic J
Org Biomol Chem
. 2017 Jan;
15(6):1350-1354.
PMID: 28116387
Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of N-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods....
4.
Reddy Y, Al Temimi A, White P, Mecinovic J
Org Lett
. 2017 Jan;
19(2):400-403.
PMID: 28045275
Trimethyllysine hydroxylase (TMLH) is an Fe(II) and 2-oxoglutarate (2OG) dependent oxygenase involved in the biomedically important carnitine biosynthesis pathway. A combination of synthetic and NMR studies provides direct evidence that...
5.
Al Temimi A, Pieters B, Reddy Y, White P, Mecinovic J
Chem Commun (Camb)
. 2016 Oct;
52(87):12849-12852.
PMID: 27730239
Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(ii) and 2-oxoglutarate dependent oxygenase that catalyses the C-3 hydroxylation of an unactivated C-H bond in l-trimethyllysine in the first step of carnitine biosynthesis....
6.
Ramachary D, Venkaiah C, Reddy Y
Org Biomol Chem
. 2014 Jun;
12(29):5400-6.
PMID: 24934801
A general process for the high-yielding synthesis of substituted chiral and achiral α-substituted acrylates was achieved through the sequential one-pot combination of a metal-free reductive coupling reaction followed by an...
7.
Ramachary D, Reddy Y, Banerjee A, Banerjee S
Org Biomol Chem
. 2011 Sep;
9(21):7282-6.
PMID: 21915419
A single-step amino acid-catalyzed diastereoselective three-component synthesis of optically pure highly functionalized spiro[5,5]undecane-1,5,9-triones preferentially over the four stereoisomers was accomplished in very good yields with >99% ee/de. Preliminary cell culture-based...
8.
Ramachary D, Reddy Y
J Org Chem
. 2009 Dec;
75(1):74-85.
PMID: 19954143
Multicatalysis cascade (MCC) process for the synthesis of highly substituted chiral building blocks (2-alkyl-CH-acids, 2-alkylcyclohexane-1,3-diones, 2-alkylcyclopentane-1,3-diones, and H-P ketone analogues) is presented based on the cascade three-component reductive alkylation's (TCRA)...
9.
Ramachary D, Venkaiah C, Reddy Y, Kishor M
Org Biomol Chem
. 2009 May;
7(10):2053-62.
PMID: 19421442
In this paper we describe new multi-catalysis cascade (MCC) reactions for the one-pot synthesis of highly functionalized non-symmetrical malonates. These metal-free reactions are either five-step (olefination/hydrogenation/alkylation/ketenization/esterification) or six-step (olefination/hydrogenation/alkylation/ketenization/esterification/alkylation), and...
10.
Ramachary D, Reddy Y, Kishor M
Org Biomol Chem
. 2008 Oct;
6(22):4188-97.
PMID: 18972049
We have developed a new technology called multi-catalysis for the sequential one-pot synthesis of highly functionalized heterocycles. A practical and novel multi-component aniline-, self- and Brønsted acid-catalyzed selective process for...