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Y M Dennis Lo

Explore the profile of Y M Dennis Lo including associated specialties, affiliations and a list of published articles. Areas
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Articles 269
Citations 11227
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Recent Articles
1.
Lam W, Kang G, Chan C, Lee V, Ma M, Zhou Q, et al.
Cancer Cell . 2025 Mar; PMID: 40054465
Fragmentomics analysis of plasma autosomal DNA has shown promise in cancer diagnostics. Here we evaluated the clinical utility of plasma Epstein-Barr virus (EBV) DNA fragmentomics analysis for nasopharyngeal carcinoma (NPC)...
2.
Tsui W, Ding S, Jiang P, Lo Y
Genome Res . 2025 Jan; 35(1):1-19. PMID: 39843210
The discovery of circulating fetal and tumor cell-free DNA (cfDNA) molecules in plasma has opened up tremendous opportunities in noninvasive diagnostics such as the detection of fetal chromosomal aneuploidies and...
3.
Malki Y, Kang G, Lam W, Lam W, Zhou Q, Cheng S, et al.
Genome Res . 2024 Nov; 35(1):31-42. PMID: 39603706
The concentration of circulating cell-free DNA (cfDNA) in plasma is an important determinant of the robustness of liquid biopsies. However, biological mechanisms that lead to inter-individual differences in cfDNA concentrations...
4.
Bai J, Jiang P, Ji L, Lam W, Zhou Q, Ma M, et al.
Proc Natl Acad Sci U S A . 2024 Oct; 121(42):e2404058121. PMID: 39382996
The analysis of tissues of origin of cell-free DNA (cfDNA) is of research and diagnostic interest. Many studies focused on bisulfite treatment or immunoprecipitation protocols to assess the tissues of...
5.
Zhu G, Jiang P, Li X, Peng W, Choy L, Yu S, et al.
Clin Chem . 2024 Aug; 70(11):1355-1365. PMID: 39206580
Background: Cell-free DNA (cfDNA) analysis offers an attractive noninvasive means of detecting and monitoring diseases. cfDNA cleavage patterns within a short range (e.g., 11 nucleotides) have been reported to correlate...
6.
Lam W, Gai W, Bai J, Tam T, Cheung W, Ji L, et al.
NPJ Genom Med . 2024 Aug; 9(1):39. PMID: 39103426
The tissues of origin of plasma DNA can be revealed by methylation patterns. However, the relative DNA contributions from megakaryocytes and erythroblasts into plasma appeared inconsistent among studies. To shed...
7.
Gai W, Wang G, Lam W, Yuen L, Jiang P, Yu S, et al.
Clin Chem . 2024 Jun; 70(8):1046-1055. PMID: 38873917
Background: The analysis of haplotypes of variants is important for pharmacogenomics analysis and noninvasive prenatal testing for monogenic diseases. However, there is a lack of robust methods for targeted haplotyping....
8.
Lo Y
N Engl J Med . 2024 Mar; 390(11):1047-1050. PMID: 38477993
No abstract available.
9.
Yu S, Lo Y
Clin Chem . 2024 Mar; 70(6):789-791. PMID: 38451049
No abstract available.
10.
Che H, Jiang P, Choy L, Cheng S, Peng W, Chan R, et al.
Genome Res . 2024 Feb; 34(2):189-200. PMID: 38408788
Recent studies have revealed an unexplored population of long cell-free DNA (cfDNA) molecules in human plasma using long-read sequencing technologies. However, the biological properties of long cfDNA molecules (>500 bp)...