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Y Ilan

Explore the profile of Y Ilan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 157
Citations 925
Followers 0
Related Specialties
General Medicine
Gastroenterology
General Surgery
Top 10 Co-Authors
A Eid
D Shouval
R Safadi
E Galun
Y Ashur
A Nagler
O Jurim
R Tur-Kaspa
R Alper
E Goldin
Published In
Transplant Proc
Harefuah
Bone Marrow Transplant
Biochim Biophys Acta
Clin Exp Immunol
Affiliations
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Recent Articles
1.
Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: a novel gut-immune system-based therapy for metaflammation and NASH
Ilan Y, Shailubhai K, Sanyal A
Clin Exp Immunol . 2018 Jun; 193(3):275-283. PMID: 29920654
The immune system plays a role in the pathogenesis of non-alcoholic steatohepatitis (NASH) underlying hepatocyte injury and fibrosis progression at all disease stages. Oral administration of anti-CD3 monoclonal antibody (mAb)...
2.
Attenuating the rate of total body fat accumulation and alleviating liver damage by oral administration of vitamin D-enriched edible mushrooms in a diet-induced obesity murine model is mediated by an anti-inflammatory paradigm shift
Rotnemer-Golinkin D, Avni S, Drori A, Danay O, Levanon D, Tam J, et al.
BMC Gastroenterol . 2017 Nov; 17(1):130. PMID: 29179679
Background: Hypovitaminosis D is associated with many features of the metabolic syndrome, including non-alcoholic fatty liver disease. Vitamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect. The aim of the...
3.
Review article: novel methods for the treatment of non-alcoholic steatohepatitis - targeting the gut immune system to decrease the systemic inflammatory response without immune suppression
Ilan Y
Aliment Pharmacol Ther . 2016 Oct; 44(11-12):1168-1182. PMID: 27778363
Background: The systemic immune system plays a role in inflammation and fibrogenesis associated with non-alcoholic steatohepatitis (NASH) and has become a potential target for drug development. In particular, the gut...
4.
Late Relapse in Hodgkin's Disease: Report of Five Cases and a Review of the Literature
Ilan Y, Ruchlemer R, Lugassy G, Uzielly B, Williams S, Golomb H, et al.
Leuk Lymphoma . 2016 Jul; 5(4):249-54. PMID: 27467847
During the past 15 years the treatment of Hodgkin's disease (HD) with chemo/radiotherapy has been shown to appreciably improve the long-term prognosis of patients, even those with more advanced disease....
5.
Oral administration of non-absorbable delayed release 6-mercaptopurine is locally active in the gut, exerts a systemic immune effect and alleviates Crohn's disease with low rate of side effects: results of double blind Phase II clinical trial
Israeli E, Goldin E, Fishman S, Konikoff F, Lavy A, Chowers Y, et al.
Clin Exp Immunol . 2015 Apr; 181(2):362-72. PMID: 25846055
Therapy for Crohn's disease (CD) with thiopurines is limited by systemic side effects. A novel formulation of fixed-dose, delayed-release 6-mercaptopurine (DR-6MP) was developed, with local effect on the gut immune...
6.
Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial
Halota W, Ferenci P, Kozielewicz D, Dybowska D, Lisovoder N, Samira S, et al.
J Viral Hepat . 2014 Nov; 22(8):651-7. PMID: 25412903
Unlabelled: Orally administered anti-CD3 antibodies are biologically active in the gut through induction of regulatory T cells, exert an immune-modulatory effect, and alleviate insulin resistance and liver damage in patients...
7.
Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells
Adar T, Yaacov A, Lalazar G, Lichtenstein Y, Nahman D, Mizrahi M, et al.
Clin Exp Immunol . 2012 Jan; 167(2):252-60. PMID: 22236001
Insulin resistance and metabolic syndrome are chronic inflammatory conditions that lead to hepatic injury and non-alcoholic steatohepatitis (NASH). Bovine colostrum has therapeutic effects in a variety of chronic infections. However...
8.
Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
Avraham Y, Grigoriadis N, Poutahidis T, Vorobiev L, Magen I, Ilan Y, et al.
Br J Pharmacol . 2010 Dec; 162(7):1650-8. PMID: 21182490
Background And Purpose: Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure. We investigated the effects of cannabidiol, a non-psychoactive constituent of Cannabis...
9.
Beta glycosphingolipids suppress rank expression and inhibit natural killer T cell and CD8+ accumulation in alleviating aortic valve calcification
Shuvy M, Yaacov A, Zolotarov L, Lotan C, Ilan Y
Int J Immunopathol Pharmacol . 2010 Jan; 22(4):911-8. PMID: 20074454
CD8 lymphocytes play a role in aortic valve inflammation leading to aortic valve calcification (AVC). RANK is a transmembrane protein that is important in osteoclast differentiation and calcification. Beta-glucosylceramide (beta-GC)...
10.
Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?
Ilan Y
Clin Exp Immunol . 2009 Oct; 158(3):300-7. PMID: 19793337
Natural killer T (NKT) lymphocytes are a unique subset of cells that play a role in regulating the immune system. For the past decade, studies have focused upon attempts to...