Y Bruce Yu
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Explore the profile of Y Bruce Yu including associated specialties, affiliations and a list of published articles.
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31
Citations
252
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Recent Articles
1.
Song J, Taraban M, Yu Y, Lu L, Biswas P, Xu W, et al.
MAbs
. 2024 Feb;
16(1):2304624.
PMID: 38299343
High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the potential for enhanced aggregation and increased viscosity. The analysis of...
2.
Briggs K, Taraban M, Yu Y
Hum Vaccin Immunother
. 2023 May;
19(2):2215152.
PMID: 37254504
Vaccine sedimentation and resuspension are properties that vaccine makers use to characterize a suspension product during research and development as well as throughout the shelf life of the vaccine. Three...
3.
Taraban M, Ndungu T, Karki P, Li K, Fung G, Kirkitadze M, et al.
Pharm Res
. 2023 May;
40(8):1989-1998.
PMID: 37127780
Purpose: To evaluate wNMR, an emerging noninvasive analytical technology, for characterizing aluminum-adjuvanted vaccine formulations. Methods: wNMR stands for water proton nuclear magnetic resonance. In this work, wNMR and optical techniques...
4.
Marin A, Taraban M, Patel V, Yu Y, Andrianov A
Molecules
. 2022 Nov;
27(21).
PMID: 36364250
The in vivo potency of polyphosphazene immunoadjuvants is inherently linked to the ability of these ionic macromolecules to assemble with antigenic proteins in aqueous solutions and form physiologically stable supramolecular...
5.
Briggs K, Taraban M, Yu Y
Vaccine
. 2020 Jun;
38(31):4853-4860.
PMID: 32482461
Aluminum-adjuvanted vaccines are freeze-sensitive products that require attentive cold chain adherence. Freeze/thaw events can be tested using "The World Health Organization Shake Test", a qualitative test whereby a vial from...
6.
Taraban M, Briggs K, Merkel P, Yu Y
Anal Chem
. 2019 Sep;
91(21):13538-13546.
PMID: 31550145
Continuous manufacturing of biologics is one of the priorities of the biopharmaceutical industry. However, its widespread implementation is hampered by a lack of noninvasive/nondestructive process analytical technology (PAT) systems capable...
7.
Briggs K, Taraban M, Wang W, Yu Y
AAPS PharmSciTech
. 2019 Jun;
20(5):214.
PMID: 31172314
Typesetting error occurred and author corrections to the equations and text edits at the proofing stage were not incorporated in the published article. The original article has been corrected.
8.
Briggs K, Taraban M, Wang W, Yu Y
AAPS PharmSciTech
. 2019 May;
20(5):189.
PMID: 31111256
Batch-level inference-based quality control is the standard practice for drug products. However, rare drug product defects may be missed by batch-level statistical sampling, where a subset of vials in a...
9.
Taraban M, DePaz R, Lobo B, Yu Y
Anal Chem
. 2019 Feb;
91(6):4107-4115.
PMID: 30767509
Water proton transverse relaxation rate R(HO) measurements by NMR stand out as a powerful noninvasive tool to detect protein aggregates, including subvisible particles in biopharmaceutical formulations. To understand the applicability...
10.
Briggs K, Taraban M, Yu Y
Chem Commun (Camb)
. 2018 Jun;
54(51):7003-7006.
PMID: 29850691
The transverse relaxation rate of water protons R2(1H2O) is found to be sensitive to amide hydrolysis and diglycine dimerization. The results demonstrate the feasibility of using R2(1H2O) as a diagnostic...