Xu-Dong Kong
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Explore the profile of Xu-Dong Kong including associated specialties, affiliations and a list of published articles.
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28
Citations
346
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Recent Articles
1.
2.
Zhu X, Zheng W, Xia Z, Chen X, Jin T, Ding X, et al.
Nat Commun
. 2024 Nov;
15(1):10330.
PMID: 39609402
The stereoselectivity of enzymes plays a central role in asymmetric biocatalytic reactions, but there remains a dearth of evolution-driven biochemistry studies investigating the evolutionary trajectory of this vital property. Imine...
3.
Han Y, Luo Y, Ma B, Li J, Xu J, Kong X
Biochemistry
. 2024 May;
63(12):1578-1587.
PMID: 38803051
l-(+)-Tartaric acid plays important roles in various industries, including pharmaceuticals, foods, and chemicals. -Epoxysuccinate hydrolases (CESHs) are crucial for converting -epoxysuccinate to l-(+)-tartrate in the industrial production process. There is,...
4.
He R, Zhang M, Dai B, Kong X
ACS Chem Biol
. 2024 Apr;
19(5):1040-1044.
PMID: 38620022
Cysteine conjugation is widely used to constrain phage displayed peptides for the selection of cyclic peptides against specific targets. In this study, the nontoxic Bi ion was used as a...
5.
Sun C, Ma B, Li G, Tian W, Yang L, Peng H, et al.
Angew Chem Int Ed Engl
. 2023 Apr;
62(25):e202304994.
PMID: 37083030
Heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are an important class of bioactive secondary metabolites. Biosynthesis offers a practical opportunity to access their bioactive structural diversity, however, it is restricted by the limited...
6.
Wang R, Pu Z, Janke J, Zheng Y, Kong X, Niu T, et al.
J Agric Food Chem
. 2023 Feb;
71(8):3852-3861.
PMID: 36790033
Ginsenosides are the main bioactive ingredients in plants of the genus . -ginsenoside R7 (VG-R7) is one of the rare high-value ginsenosides with health benefits. The only reported method for...
7.
Carle V, Kong X, Comberlato A, Edwards C, Diaz-Perlas C, Heinis C
Protein Eng Des Sel
. 2021 Aug;
34.
PMID: 34341825
Phage display is a powerful technique routinely used for the generation of peptide- or protein-based ligands. The success of phage display selections critically depends on the size and structural diversity...
8.
Kong X, Heinis C
Chimia (Aarau)
. 2021 Jul;
75(6):514-517.
PMID: 34233815
Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their high target specificity, and their non-toxic...
9.
Stevens C, Bachtiger F, Kong X, Abriata L, Sosso G, Gibson M, et al.
Nat Commun
. 2021 May;
12(1):2675.
PMID: 33976148
Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure-property relationships that have been established for...
10.
Carle V, Wu Y, Mukherjee R, Kong X, Rogg C, Laurent Q, et al.
J Med Chem
. 2021 May;
64(10):6802-6813.
PMID: 33974422
Coagulation factor XI (FXI) has emerged as a promising target for the development of safer anticoagulation drugs that limit the risk of severe and life-threatening bleeding. Herein, we report the...