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Xiuling Han

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Articles 18
Citations 45
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Recent Articles
1.
Chen J, Han X, Lu X
Org Biomol Chem . 2020 Oct; 18(43):8850-8853. PMID: 33119022
A palladium(ii)-catalyzed cyclization of 2-ethynylaniline tethered cinnamyl acetate involving aminopalladation/alkene insertion/β-acetoxy elimination cascade processes was established. The new protocol provides efficient access to indenoindoles in moderate to good yields under...
2.
Chen J, Han X, Lu X
Org Lett . 2019 Sep; 21(20):8153-8157. PMID: 31557039
A novel Pd(II)-catalyzed reductive asymmetric cyclization of -tosyl-tethered 1,7-enynes using ethanol as a hydrogen source is reported. This reaction provides facile ways for the synthesis of two types of 1,2,3,4-tetrahydroquinolines...
3.
Chen J, Han X, Lu X
Org Lett . 2018 Nov; 20(23):7470-7473. PMID: 30484664
A Pd(OAc)-catalyzed asymmetric cyclization of 2-aminoaryl alkynones involving an intramolecular trans-aminopalladation of alkyne and 1,2-addition to the carbonyl group tandem processes was developed. This strategy represents the first example using...
4.
Wu W, Chen T, Chen J, Han X
J Org Chem . 2017 Dec; 83(2):1033-1040. PMID: 29260559
A cationic palladium(II)-catalyzed reductive cyclization of cyclohexadienone-containing 1,6-enynes by using ethanol as a hydrogen donor and solvent was successfully developed. This procedure offers convenient access to cyclohexenone-annulated heterocycles under mild...
5.
Chen J, Han X, Lu X
Angew Chem Int Ed Engl . 2017 Sep; 56(46):14698-14701. PMID: 28960649
A novel palladium(II)-catalyzed cyclization of aniline-tethered alkynyl cyclohexadienones is reported. This reaction offers an atom-economical and redox-neutral access to various cyclohexenone-fused tetrahydropyrano[3,4-b]indoles with high yield and excellent enantioselectivity. Remarkably, this...
6.
Chen J, Han X, Lu X
J Org Chem . 2017 Jan; 82(4):1977-1985. PMID: 28088855
An atom-economic Pd(OAc)-catalyzed tandem cyclization of alkynones to synthesize pentaleno[2,1-b]indoles was developed efficiently. In the formed tetracyclic indole framework, two neighboring stereocenters, one being all-carbon quaternary, are being constructed in...
7.
Zhang J, Han X, Lu X
Org Lett . 2016 May; 18(12):2898-901. PMID: 27228381
A Pd(OAc)2-catalyzed cyclization reaction of ortho-electron-deficient alkynyl-substituted aryl aldehydes with indoles was accomplished, providing an efficient and economical way to synthesize indole-substituted indanones. The electron-withdrawing group attached to the alkyne...
8.
Zhang J, Han X, Lu X
J Org Chem . 2016 Mar; 81(8):3423-9. PMID: 26999527
A cationic Pd(II)-catalyzed cascade cyclization reaction of alkyne-tethered carbonyl compounds was developed. This reaction is initiated by intramolecular oxypalladation of alkynes with an ester group followed by 1,2-addition of the...
9.
Zhang X, Han X, Lu X
Org Lett . 2015 Jul; 17(15):3910-3. PMID: 26208137
An efficient cyclization of N-tosyl-aniline tethered allenyl aldehydes and arylboronic acids catalyzed by cationic palladium complex is developed. This annulation reaction provides a convenient process for the synthesis of 3,4-cis-1,2,3,4-tetrahydroquinoline...
10.
Xia G, Han X, Lu X
Org Lett . 2014 Nov; 16(23):6184-7. PMID: 25402650
A palladium(II)-catalyzed efficient synthesis of heterocycle-fused β-naphthylamines was accomplished via nucleophilic addition of a carbon-palladium bond to the intramolecular cyano group initiated by nucleopalladation (oxypalladation or aminopalladation) of alkynes.