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Xinzhe Feng

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Recent Articles
1.
Qiao J, Zhou B, Han C, Xu Q, Feng X, Xu W
Biochem Biophys Res Commun . 2024 Dec; 745:151255. PMID: 39740396
Background: Ankylosing spondylitis (AS) is an autoimmune disease characterized by dysfunction of the immune system, which leads to chronic inflammation and progressive ossification of spinal ligaments. The precise pathogenesis of...
2.
Ji Z, Feng X, Han C, Li S, Wu B, Zhang X, et al.
Int Immunopharmacol . 2024 Nov; 144:113653. PMID: 39566386
Ankylosing spondylitis (AS) is a motor system immune disease with significant genetic characteristics, resulting in joint fusion, deformity, rigidity, seriously affecting the quality of life of patients. Inflammatory bowel disease...
3.
Fang C, Zhong R, Lu S, Yu G, Liu Z, Yan C, et al.
Int J Biol Sci . 2024 Apr; 20(6):1992-2007. PMID: 38617547
Osteoarthritis (OA) is the most prominent chronic arthritic disease, affecting over 3 billion people globally. Synovial macrophages, as immune cells, play an essential role in cartilage damage in OA. Therefore,...
4.
Fang C, Zhu S, Zhong R, Yu G, Lu S, Liu Z, et al.
Heliyon . 2024 Mar; 10(5):e27466. PMID: 38463824
Objective: Chondrocyte death is the hallmark of cartilage degeneration during osteoarthritis (OA). However, the specific pathogenesis of cell death in OA chondrocytes has not been elucidated. This study aims to...
5.
Feng X, Wang C, Ji B, Qiao J, Xu Y, Zhu S, et al.
Ann Rheum Dis . 2023 Nov; 83(3):324-334. PMID: 37977819
Objectives: This study aimed to identify the types and heterogeneity of cells within the spinal enthesis and investigate the underlying mechanisms of osteogenesis. Methods: Single-cell RNA sequencing was used to...
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7.
Feng X, Zhu S, Qiao J, Ji Z, Zhou B, Xu W
J Transl Med . 2023 Aug; 21(1):573. PMID: 37626378
Background: Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints. Many AS patients also have inflammatory...
8.
Feng X, Tong W, Li J, Xu Y, Zhu S, Xu W
Front Immunol . 2023 Apr; 14:1156350. PMID: 37063878
Objective: Axial spondyloarthritis (axSpA) is a chronic rheumatic disease predominantly characterized by inflammation and progressive structural damage. Patients are often diagnosed very late, which delays the optimal treatment period. Early...
9.
Tong W, Li J, Feng X, Wang C, Xu Y, He C, et al.
Int J Mol Med . 2021 Feb; 47(4). PMID: 33576467
Bone homeostasis is maintained by a dynamic balance between bone formation and bone resorption. The cellular activities of osteoblasts and osteoclasts are the primary factors that maintain this dynamic balance....
10.
Feng X, Zhu S, Yan Z, Wang C, Tong W, Xu W
Cell Mol Biol (Noisy-le-grand) . 2020 Oct; 66(6):127-134. PMID: 33040798
Ankylosing spondylitis (AS) is a chronic, progressive, and inflammatory disease that mainly affects the central axis joint. Although this disease has already been well documented and studied, its pathogenesis is...